GNA12 and S1PR5

Number of citations of the paper that reports this interaction (PMID 11069896)
15

Data Source:
HPRD (in vitro)

		GNA12	S1PR5
Gene Name		guanine nucleotide binding protein (G protein) alpha 12	sphingosine-1-phosphate receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Brush Border Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Sphingosine-1-phosphate Receptor Activity
	Biological Process	In Utero Embryonic Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis	Sphingosine-1-phosphate Signaling Pathway Regulation Of Neuron Differentiation
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling G alpha (12/13) signalling events Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Height ( 20881960 19343178 18391951 20189936) Ulcerative colitis ( 23128233 21297633) White matter integrity ( 23218918)
Protein-Protein Interactions		30 interactors: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 RHOA S1PR4 S1PR5 TBXA2R TEC TSHR	4 interactors: GNA12 GNAI1 GNAO1 SGPP1
Entrez ID		2768	53637
HPRD ID		05093	05510
Ensembl ID		ENSG00000146535	ENSG00000180739
Uniprot IDs		B3KXS2 E9PC54 Q03113 Q6ZQV4	Q9H228
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cellular Response To Stimulus Cellular Calcium Ion Homeostasis Blood Coagulation Regulation Of Body Fluid Levels Calcium Ion Homeostasis Hemostasis Response To Organic Substance Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Metal Ion Homeostasis Apoptotic Process Programmed Cell Death Cellular Cation Homeostasis Cellular Ion Homeostasis Cell Death Death Metal Ion Homeostasis Regulation Of Signaling Chemical Homeostasis Response To Stimulus Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Homeostatic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Cellular Homeostasis Neurotrophin TRK Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To External Stimulus Neurotrophin Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Sphinganine-1-phosphate Metabolic Process Platelet Activation G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Sphingosine Metabolic Process Signal Transduction Response To Drug Signaling Regulation Of Body Fluid Levels Cell Communication Wound Healing Cell Activation Response To Wounding Regulation Of Fibroblast Migration Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Response To Morphine Negative Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Vesicle Fusion Rho Protein Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling
Tagcloud ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	aqpep bcl2l11 clic6 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal slc35d3 tbx4 tfap2c xrn2
Tagcloud (Difference) ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	aqpep bcl2l11 clic6 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal slc35d3 tbx4 tfap2c xrn2
Tagcloud (Intersection) ?