GNA12 and ARHGEF12

Number of citations of the paper that reports this interaction (PubMedID 12515866)
28

Data Source:
HPRD (in vivo, in vitro)

		GNA12	ARHGEF12
Description		G protein subunit alpha 12	Rho guanine nucleotide exchange factor 12
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GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Lateral Plasma Membrane Brush Border Membrane Neuron Projection Neuronal Cell Body	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding Protein Phosphatase 2A Binding Protein Phosphatase Activator Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Regulation Of Cell Shape Response To Xenobiotic Stimulus Regulation Of Fibroblast Migration Cell Differentiation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Embryonic Digit Morphogenesis Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Height ( 19343178 31562340 28552196 20189936 20881960 18391951 25282103 25429064) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Medial thalamic nuclei volume ( 34006833) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 28928442 27182965) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Weight ( 28552196) White matter integrity ( 23218918)	Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 30054594 31798171 29785010 29617998 31959993 29235454 28073927 25637523) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR	18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VANGL2
Entrez ID		2768	23365
HPRD ID		05093	09207
Ensembl ID		ENSG00000146535	ENSG00000196914
Uniprot IDs		E9PC54 Q03113 Q6ZQV4	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		7YDJ	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Plasma Membrane G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Membrane Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of Transport Positive Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Junction Organization Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Regulation Of Protein Localization Adherens Junction Organization Cell-cell Junction Assembly Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Protein Localization Presynapse G Protein-coupled Receptor Activity Histone H3T6 Kinase Activity Cellular Response To Catecholamine Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Rho Protein Signal Transduction Response To Catecholamine Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Transport Positive Regulation Of Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of Protein Localization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Blood Pressure Cell Junction Organization Regulation Of MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Intracellular Signal Transduction Catenin Complex Extracellular Exosome Regulation Of Superoxide Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid	Regulation Of Cellular Component Organization Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Cell Shape Regulation Of Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endocytic Vesicle Regulation Of Developmental Process D5 Dopamine Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Cell Migration Positive Regulation Of Rho Protein Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Motility Lysophosphatidic Acid Receptor Activity Cell Motility Regulation Of Locomotion Protein Tyrosine Kinase Activity Apolipoprotein A-I-mediated Signaling Pathway Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Anatomical Structure Morphogenesis Nucleotide Binding Ossification Involved In Bone Maturation Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Focal Adhesion Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Semaphorin Receptor Activity Transmembrane Signaling Receptor Activity Semaphorin Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Organization Basolateral Plasma Membrane Negative Regulation Of Intracellular Signal Transduction
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