GNA12 and AKAP13

Number of citations of the paper that reports this interaction (PMID 11546812)
65

Data Source:
HPRD (in vitro, in vivo)

		GNA12	AKAP13
Gene Name		guanine nucleotide binding protein (G protein) alpha 12	A kinase (PRKA) anchor protein 13
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Brush Border Membrane	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	CAMP-dependent Protein Kinase Activity Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Protein Complex Scaffold Metal Ion Binding Protein Kinase A Binding
	Biological Process	In Utero Embryonic Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis	Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Apoptotic Signaling Pathway Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling G alpha (12/13) signalling events Platelet activation, signaling and aggregation	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Height ( 20881960 19343178 18391951 20189936) Ulcerative colitis ( 23128233 21297633) White matter integrity ( 23218918)	Central corneal thickness ( 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		30 interactors: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 RHOA S1PR4 S1PR5 TBXA2R TEC TSHR	20 interactors: CTNNAL1 DYT10 ESR1 ESR2 GNA12 GNAQ MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB THRA YWHAB YWHAE YWHAG YWHAZ
Entrez ID		2768	11214
HPRD ID		05093	05253
Ensembl ID		ENSG00000146535	ENSG00000170776
Uniprot IDs		B3KXS2 E9PC54 Q03113 Q6ZQV4	B0AZU4 Q12802
PDB IDs			2DRN 2LG1
Enriched GO Terms of Interacting Partners?		Platelet Activation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cellular Response To Stimulus Cellular Calcium Ion Homeostasis Blood Coagulation Regulation Of Body Fluid Levels Calcium Ion Homeostasis Hemostasis Response To Organic Substance Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Metal Ion Homeostasis Apoptotic Process Programmed Cell Death Cellular Cation Homeostasis Cellular Ion Homeostasis Cell Death Death Metal Ion Homeostasis Regulation Of Signaling Chemical Homeostasis Response To Stimulus Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Homeostatic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Cellular Homeostasis Neurotrophin TRK Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To External Stimulus Neurotrophin Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway	Cell Communication Signal Transduction Cellular Response To Stimulus Cellular Response To Organic Substance Signaling Cellular Response To Hormone Stimulus Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Response To Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Hormone Positive Regulation Of Intracellular Transport Intracellular Signal Transduction Regulation Of Cellular Localization Hormone-mediated Signaling Pathway Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Positive Regulation Of Mitochondrion Organization Transcription Initiation From RNA Polymerase II Promoter Apoptotic Signaling Pathway Cellular Response To Steroid Hormone Stimulus Wound Healing Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Platelet Activation Apoptotic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Programmed Cell Death Positive Regulation Of Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Phospholipase Activity Response To Wounding Positive Regulation Of Lipase Activity Ras Protein Signal Transduction Blood Coagulation Cell Death Death Neurotrophin Signaling Pathway Hemostasis DNA-templated Transcription, Initiation Regulation Of Mitochondrion Organization Negative Regulation Of Kinase Activity
Tagcloud ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Difference) ?		anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Intersection) ?