CDK1 and SFN

Number of citations: 0 (PubMedID 10524633)
Data Source: HPRD (in vivo)

		CDK1	SFN
Name		cyclin dependent kinase 1	stratifin
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Virus Receptor Activity Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Amine Response To Activity Cell Migration Protein Deubiquitination Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Thymidine Biosynthetic Process Response To Cadmium Ion Response To Copper Ion Symbiont Entry Into Host Cell Microtubule Polymerization Fibroblast Proliferation Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cilium Disassembly Positive Regulation Of Mitotic Sister Chromatid Segregation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Protein Localization To Site Of Double-strand Break Mitotic DNA-templated DNA Replication	Negative Regulation Of Transcription By RNA Polymerase II Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Signal Transduction Intracellular Protein Localization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell-cell Adhesion Keratinocyte Differentiation Positive Regulation Of Cell Growth Keratinization Regulation Of Protein Localization Defense Response To Bacterium Skin Development Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Innate Immune Response Positive Regulation Of Protein Export From Nucleus Cytolysis In Another Organism Regulation Of Cell Cycle Establishment Of Skin Barrier Stem Cell Proliferation CAMP/PKA Signal Transduction Non-canonical Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Stem Cell Proliferation
Pathways		MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerization of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2 PKR-mediated signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib Avotaciclib	None
GWAS		Cocaine dependence ( 23958962 ) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298 )	Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Eosinophil percentage of white cells ( 32888494 ) Neutrophil percentage of granulocytes ( 27863252 )
Interacting Genes		241 interacting genes: ABL1 ACSL4 ADD1 AKAP12 AKT1 AMPH APLP2 AR ARID4A BARD1 BCL2 BCL2L11 BIRC5 BIRC6 BRCA1 BRCA2 BTG2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEBPA CENPF CEP55 CEP63 CHAF1B CIITA CIP2A CKS2 CNOT7 CREB1 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUL4B CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EML3 EPN1 ERCC2 ERCC6L FANCA FANCC FANCG FBXO5 FEN1 FLNA FOXM1 FOXO1 FYN GADD45A GADD45B GADD45G GAS2L3 GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HASPIN HJURP HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 ID2 IDH1 IDH2 IL16 IL3RA IQGAP1 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LRRK1 LYN LZTS1 MAP4 MAPK12 MAPT MBP MCM2 MCM4 MDM4 MEF2C MIS18BP1 MISP MKI67 MLKL MLST8 MNDA MYC MYT1 NCAPD2 NCAPD3 NCAPG NCAPH NCL NDE1 NEDD1 NES NHERF1 NONO NPM1 NSFL1C NUP210 PAK6 PBK PCM1 PCNA PIN1 PIP5K1C PITPNM1 PKMYT1 PLEC PML POLA1 POLL PON1 PPP1R12A PPP2R1A PPP2R1B PPP2R2B PPP4R2 PPP4R3A PRC1 PRDX1 PRDX2 PRKAR2A PSRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAD9A RANGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA2 RPS3 RPS6KB1 RRM2 RSF1 RUNX1 RUNX2 SAMHD1 SFN SLBP SOX2 SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TERF1 TFDP1 TGFBR2 TK1 TLE1 TMPO TNNC1 TOP2A TP53 TP53BP1 TP73 TPR TSC1 TSPYL2 TUBB UBA1 UBE2A UBE3A UHRF2 USP14 USP16 VHL VIM WAC WEE1 XIAP XPO1 XRCC6 ZBTB16	62 interacting genes: ABL1 ARAF BAD BAX BCR BRAF CCAR1 CCDC102B CCDC125 CCNH CDC25B CDK1 CHST1 COP1 DUXAP9 EEF1A1 EGFR EIF2S1 EIF4B ENTREP1 EXO1 FAM53C FAM9B FOXO1 FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LNX2 LONRF1 MAGEA1 MAP1A MAP3K5 MARK3 MDM4 MKRN3 MST1R NFIA NFIB NFIC NR3C1 NTAQ1 PAX9 PLEKHF2 PLK4 RAB3IP RAF1 RFFL RNF126 SAMSN1 TBL3 TP53 TRIM25 TSC2 YWHAG ZC2HC1C ZFP36
Entrez ID		983	2810
HPRD ID		00302	03185
Ensembl ID		ENSG00000170312	ENSG00000175793
Uniprot IDs		B7Z3D6 I6L9I5 P06493	P31947
PDB IDs		4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7 6TWN 7NJ0	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6T5F 6T5H 6T80 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6XXC 6XY5 6Y18 6Y1D 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y3W 6Y40 6Y44 6Y58 6Y7T 6Y8A 6Y8B 6Y8D 6Y8E 6YE9 6YIA 6YIB 6YIC 6YLU 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 6YR5 6YR6 6YR7 6ZCJ 6ZVB 6ZVC 6ZVD 6ZVE 7AEW 7AOG 7AXN 7AYF 7AZ1 7AZ2 7B13 7B15 7B9M 7B9R 7B9T 7BA3 7BA5 7BA6 7BA7 7BA8 7BA9 7BAA 7BAB 7BDP 7BDT 7BDY 7BFW 7BG3 7BGQ 7BGR 7BGV 7BGW 7BI3 7BIQ 7BIW 7BIY 7BJB 7BJF 7BJL 7BJW 7BKH 7BM9 7BMC 7NFW 7NIF 7NIG 7NIX 7NIZ 7NJ6 7NJ8 7NJ9 7NJA 7NJB 7NK3 7NK5 7NLA 7NLE 7NM1 7NM3 7NM9 7NMA 7NMH 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7NQP 7NR7 7NRK 7NRL 7NSV 7NV4 7NVI 7NWS 7NXS 7NXT 7NXW 7NXY 7NY4 7NYE 7NYF 7NYG 7NZ6 7NZG 7NZK 7NZV 7O07 7O34 7O3A 7O3F 7O3P 7O3Q 7O3R 7O3S 7O57 7O59 7O5A 7O5C 7O5D 7O5F 7O5G 7O5O 7O5P 7O5S 7O5U 7O5X 7O6F 7O6G 7O6I 7O6J 7O6K 7O6M 7O6O 7OB5 7OB8 7OBC 7OBD 7OBG 7OBH 7OBK 7OBL 7OBS 7OBT 7OBX 7OBY 7OPW 7OQ7 7OQ8 7OQ9 7OQA 7OQG 7OQJ 7OQS 7OQU 7OQW 7OR3 7OR5 7OR7 7OR8 7ORG 7ORH 7ORS 7ORT 7PWT 7PWZ 7QIK 7QIP 7ZMU 7ZMW 8A62 8A65 8A68 8A6F 8A6H 8ADM 8AFN 8AI0 8ALR 8ALT 8ALV 8ALW 8AM7 8ANB 8ANC 8ANF 8AOY 8APS 8AQ1 8AQC 8AQE 8AQZ 8AR4 8AR5 8ARG 8ARO 8ARQ 8ARR 8ARW 8ARX 8ARY 8ARZ 8AS1 8AT9 8ATP 8ATR 8ATS 8AU2 8AUS 8AUY 8AV0 8AV3 8AV4 8AV7 8AV8 8AWG 8AXE 8AXU 8AZE 8B2I 8B2K 8B39 8B4Q 8B5P 8BFC 8BI7 8BJG 8BJN 8BM5 8BTQ 8BWE 8BWH 8BWJ 8BWX 8BWZ 8BX0 8BX3 8BX4 8BXI 8BXM 8BXN 8BXO 8BXQ 8BXS 8BY9 8BYB 8BYC 8BYD 8BYE 8BYF 8BYG 8BYO 8BYY 8BYZ 8BZ0 8BZ9 8BZA 8BZB 8BZC 8BZD 8BZE 8BZF 8BZG 8BZH 8BZT 8BZW 8C04 8C0K 8C0L 8C1Y 8C28 8C2D 8C2E 8C2F 8C2G 8C2Y 8C30 8C3C 8C3Z 8C40 8C42 8C43 8C4F 8C4G 8P0D 8Q4L 8Q55 8Q5C 8R0Z 8RRK 8RRL 8RRM 8S42 9AXA 9F35
GO Terms Enriched among Interactors		Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Nucleus Cellular Response To Stress Nucleoplasm DNA Damage Response Regulation Of Mitotic Cell Cycle Organelle Organization Cytosol Cytoplasm Regulation Of Cell Cycle Phase Transition Chromosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cell Cycle Phase Transition Intracellular Signal Transduction Positive Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization DNA Metabolic Process Response To Stress Negative Regulation Of Macromolecule Metabolic Process DNA Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cytoskeleton Regulation Of DNA Metabolic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Apoptotic Process Protein Kinase Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Cell Cycle G2/M Phase Transition Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Component Assembly Negative Regulation Of Mitotic Cell Cycle	MAP Kinase Kinase Kinase Activity Regulation Of Protein Metabolic Process Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation MAPK Cascade Kinase Activity Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Wounding Protein Metabolic Process Cellular Response To Oxidative Stress Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Action Potential Firing Rate Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Response To Starvation Potassium Ion Leak Channel Activity Regulation Of Macromolecule Metabolic Process Programmed Cell Death Cell Death Cellular Response To Reactive Nitrogen Species Nucleus Protein Serine Kinase Activity Cellular Response To Acidic PH Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Cellular Response To Chemical Stress Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Starvation Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of DNA-templated Transcription Response To Nutrient Levels Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Programmed Cell Death