BIRC3 and PACS2

Number of citations of the paper that reports this interaction (PubMedID 24633224)
44

Data Source:
BioGRID (pull down)

		BIRC3	PACS2
Description		baculoviral IAP repeat containing 3	phosphofurin acidic cluster sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Mitochondrion Endoplasmic Reticulum
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Transmembrane Transporter Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Spermatogenesis Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Autophagosome Assembly Apoptotic Process Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization To Phagophore Assembly Site Protein Localization To Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		37 interacting genes: BIRC5 CASP3 CASP7 CASP9 CD40 CTBP2 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1	4 interacting genes: BIRC2 BIRC3 PKD2 TRAF2
Entrez ID		330	23241
HPRD ID		03426	17816
Ensembl ID		ENSG00000023445	ENSG00000179364
Uniprot IDs		Q13489	Q86VP3
PDB IDs		2UVL 3EB5 3EB6 3M0A 3M0D 7NK0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity CD40 Receptor Complex Protein Polyubiquitination Proteolysis Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Catabolic Process Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Post-translational Protein Modification Apoptotic Signaling Pathway Protein Catabolic Process DNA Damage Response Regulation Of Metabolic Process Regulation Of Programmed Cell Death Fibroblast Apoptotic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Response To Stress Intrinsic Apoptotic Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Neuron Apoptotic Process Regulation Of Signal Transduction	Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Programmed Necrotic Cell Death Intracellular Signaling Cassette Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Programmed Necrotic Cell Death Regulation Of Toll-like Receptor Signaling Pathway Protein-containing Complex Binding Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To CAMP Cytoplasmic Side Of Plasma Membrane Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein Ubiquitination Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development TORC2 Complex Disassembly Positive Regulation Of Post-translational Protein Modification Protein-containing Complex Positive Regulation Of Protein Metabolic Process Response To Purine-containing Compound FBXO Family Protein Binding Polycystin Complex Metanephric Smooth Muscle Tissue Development Renal Artery Morphogenesis TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death
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