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BIRC3 and RAF1
Number of citations of the paper that reports this interaction (PubMedID
19011619
)
0
Data Source:
BioGRID
(pull down)
BIRC3
RAF1
Description
baculoviral IAP repeat containing 3
Raf-1 proto-oncogene, serine/threonine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Pseudopodium
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein-containing Complex Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Adenylate Cyclase Activator Activity
Kinase Activity
Transferase Activity
Enzyme Binding
Small GTPase Binding
Identical Protein Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Spermatogenesis
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of RIG-I Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
MAPK Cascade
Intracellular Glucose Homeostasis
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Schwann Cell Development
Cell Differentiation
Thyroid Gland Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Somatic Stem Cell Population Maintenance
Regulation Of Rho Protein Signal Transduction
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Muscle Stretch
ERBB2-ERBB3 Signaling Pathway
Wound Healing
Myelination
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Type B Pancreatic Cell Proliferation
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Thymus Development
Face Development
Type II Interferon-mediated Signaling Pathway
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
IFNG signaling activates MAPKs
Drugs
Sorafenib
LErafAON
XL281
iCo-007
Cholecystokinin
Regorafenib
Dabrafenib
Fostamatinib
Diseases
GWAS
Prostate cancer (
23535732
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
A body shape index (
34021172
)
Asthma (
32296059
)
Cardiac hypertrophy (
21348951
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cholesterol, total (
20686565
24097068
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol levels (
32203549
)
Hip index (
34021172
)
Total cholesterol levels (
28334899
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
26426971
34021172
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
37 interacting genes:
BIRC5
CASP3
CASP7
CASP9
CD40
CTBP2
CYFIP2
DIABLO
DZIP3
GLMN
GSPT1
HAX1
HTRA2
IKBKE
MAP3K14
MBTPS1
PACS2
PELI1
RAF1
RCHY1
RIPK3
RIPK4
SNX7
SPHK1
SUMO1
TRAF1
TRAF2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2N
UBE2Q2
UBE2V1
USP19
YOD1
161 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HECTD3
HERC1
HGF
HRAS
HSP90AA1
HSP90AB1
HSPA4
HSPA8
IL2RB
INSR
INTS10
ITCH
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB1
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SFN
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TRIM22
TSC22D3
UBE2D2
USP7
VAV1
VDAC1
WEE2-AS1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAZ
YY1
Entrez ID
330
5894
HPRD ID
03426
01265
Ensembl ID
ENSG00000023445
ENSG00000132155
Uniprot IDs
Q13489
A0A0S2Z4L5
A0A0S2Z559
B4E0X2
L7RRS6
P04049
PDB IDs
2UVL
3EB5
3EB6
3M0A
3M0D
7NK0
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
6VJJ
6XGU
6XGV
6XHA
6XHB
6XI7
7JHP
7Z37
7Z38
8A68
8A6F
8A6H
8ATR
8ATS
8AV0
8CHF
8CPD
8EPW
8GAE
8GFT
8JOF
8JOG
8S42
8T74
8T75
8U1L
9AXA
9AXC
9AY7
9AYA
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Modification Process
Ubiquitin Conjugating Enzyme Activity
Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Macromolecule Catabolic Process
Ubiquitin-protein Transferase Activity
CD40 Receptor Complex
Protein Polyubiquitination
Proteolysis
Cytosol
Ubiquitin Protein Ligase Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Programmed Cell Death
Cell Death
Protein Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cellular Response To Stress
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Ubiquitination
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Catabolic Process
Transferase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Regulation Of Primary Metabolic Process
Positive Regulation Of Signaling
Positive Regulation Of Post-translational Protein Modification
Apoptotic Signaling Pathway
Protein Catabolic Process
DNA Damage Response
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Fibroblast Apoptotic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Response To Stress
Intrinsic Apoptotic Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Protein Ubiquitination
Neuron Apoptotic Process
Regulation Of Signal Transduction
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
Regulation Of MAPK Cascade
MAPK Cascade
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Protein Kinase Activity
Cytosol
Kinase Activity
Nucleotide Binding
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Serine Kinase Activity
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
ATP Binding
Protein Serine/threonine Kinase Activity
Regulation Of Protein Metabolic Process
Protein Phosphorylation
Protein Kinase Binding
Regulation Of Protein Modification Process
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein Modification Process
Regulation Of Metabolic Process
Protein Tyrosine Kinase Activity
Negative Regulation Of Intracellular Signal Transduction
Transferase Activity
Regulation Of Multicellular Organismal Process
Cellular Response To Stress
Regulation Of Developmental Process
Cytoplasm
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Localization
Regulation Of Primary Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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