PDXDC1 and HTRA2

Number of citations of the paper that reports this interaction (PubMedID 17266347)
0

Data Source:
BioGRID (unspecified method)

		PDXDC1	HTRA2
Description		pyridoxal dependent decarboxylase domain containing 1	HtrA serine peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Intracellular Membrane-bounded Organelle	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex
	Molecular Function	Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding Cadherin Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Carboxylic Acid Metabolic Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Body mass index ( 28892062 29273807 25673413) Body mass index and triglycerides (pairwise) ( 33619380) Cholesteryl ester levels ( 31551469) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Fatty acid desaturase activity (serum) ( 30453627) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Height ( 31562340 20189936) Hip circumference ( 25673412) Metabolic syndrome ( 31589552) Metabolic traits ( 21886157) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Serum metabolite levels ( 33031748) Triglyceride levels ( 28334899 32154731 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		2 interacting genes: BCAP29 HTRA2	41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP
Entrez ID		23042	27429
HPRD ID		13789	05919
Ensembl ID		ENSG00000179889	ENSG00000115317
Uniprot IDs		B4DHL7 Q6P996 Q86XE2	A0A384MDW9 A0A8Q3SIX7 O43464
PDB IDs			1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K
Enriched GO Terms of Interacting Partners?		Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Response To Herbicide Mitochondrial Protein Catabolic Process Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Serine-type Endopeptidase Complex Negative Regulation Of Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Localization To Endoplasmic Reticulum Exit Site Positive Regulation Of Execution Phase Of Apoptosis Cell Death Apoptotic Process Cellular Response To Interferon-beta Execution Phase Of Apoptosis Protein Autoprocessing Programmed Cell Death Protein Serine/threonine Kinase Inhibitor Activity Protein Localization To Endoplasmic Reticulum Walking Behavior Adult Walking Behavior Endoplasmic Reticulum Membrane Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Response To Interferon-beta Negative Regulation Of Macroautophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Cellular Response To Heat Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Regulation Of Multicellular Organism Growth Cellular Response To Retinoic Acid Forebrain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrial Intermembrane Space Adult Locomotory Behavior Response To Heat Terpenoid Metabolic Process Ceramide Metabolic Process Response To Retinoic Acid Isoprenoid Metabolic Process Response To Toxic Substance Negative Regulation Of Autophagy Cytoplasmic Side Of Plasma Membrane Neuron Apoptotic Process	Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process
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