DESI1 and FGF7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DESI1	FGF7
Gene Name		desumoylating isopeptidase 1	fibroblast growth factor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Golgi Apparatus
	Molecular Function	Peptidase Activity Identical Protein Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Proteolysis	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways			Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS			Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Protein-Protein Interactions		2 interactors: FGF7 ZBTB46	13 interactors: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 UBQLN1
Entrez ID		27351	2252
HPRD ID		18590	01022
Ensembl ID		ENSG00000100418
Uniprot IDs		Q6ICB0	P21781 Q6FGV5
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dendritic Cell Differentiation Secretion By Lung Epithelial Cell Involved In Lung Growth Positive Regulation Of Keratinocyte Migration Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Monocyte Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Keratinocyte Proliferation Lung Growth Negative Regulation Of Granulocyte Differentiation Regulation Of Dendritic Cell Differentiation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Macrophage Differentiation Regulation Of Monocyte Differentiation Mesenchymal-epithelial Cell Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis Mesenchymal Cell Proliferation Protein Localization To Cell Surface Regulation Of Keratinocyte Proliferation Positive Chemotaxis Branching Involved In Salivary Gland Morphogenesis Hair Follicle Morphogenesis Regulation Of Immune System Process Epidermis Morphogenesis Salivary Gland Morphogenesis Salivary Gland Development Negative Regulation Of Myeloid Leukocyte Differentiation Skin Morphogenesis Exocrine System Development Regulation Of Morphogenesis Of A Branching Structure Actin Cytoskeleton Reorganization Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Myeloid Cell Differentiation Stem Cell Proliferation Hair Follicle Development Hair Cycle Process Organ Growth Hair Cycle Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cell Division Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Migration Insulin Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Gland Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Myeloid Cell Differentiation	Cellular Response To Growth Factor Stimulus Response To Growth Factor Tissue Development Extracellular Matrix Disassembly Cellular Response To Organonitrogen Compound Cellular Response To Organic Substance Skeletal System Morphogenesis Axonogenesis Bone Morphogenesis Ossification Skeletal System Development Endochondral Ossification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Organ Morphogenesis Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Embryo Development Cell Morphogenesis Involved In Differentiation Collagen Catabolic Process Inner Ear Development Response To Organic Substance Regulation Of ERK1 And ERK2 Cascade Cartilage Development Neurotrophin TRK Receptor Signaling Pathway Head Development Neuron Projection Development Collagen Metabolic Process Otic Vesicle Development Neurotrophin Signaling Pathway Response To Organonitrogen Compound Cell Projection Morphogenesis Bone Development Endochondral Bone Morphogenesis Regulation Of Signal Transduction Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Ear Development Cell Part Morphogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Connective Tissue Development Blood Vessel Development Vasculature Development Peptidyl-tyrosine Phosphorylation Inner Ear Morphogenesis Neuron Development Central Nervous System Development
Tagcloud ?			abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Difference) ?			abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Intersection) ?