DESI1 and SHISA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DESI1	SHISA5
Description		desumoylating isopeptidase 1	shisa family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding	Protein Binding WW Domain Binding
	Biological Process	Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		32 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46	9 interacting genes: ARL6IP1 COPS5 DESI1 HNRNPD SCAND1 SGTA SGTB TP53 TVP23B
Entrez ID		27351	51246
HPRD ID		18590	06290
Ensembl ID		ENSG00000100418	ENSG00000164054
Uniprot IDs		Q6ICB0	Q8N114
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?		Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle	TRC Complex Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization Establishment Of Protein Localization To Membrane Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Regulation Of Telomere Maintenance Via Telomerase Cerebellum Development Regulation Of Telomere Maintenance Via Telomere Lengthening Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Protein Metabolic Process Cellular Localization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Establishment Of Protein Localization To Organelle Negative Regulation Of Catabolic Process Regulation Of DNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Identical Protein Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Macrophage Migration Inhibitory Factor Binding Regulation Of Circadian Rhythm Regulation Of Telomere Maintenance Protein-folding Chaperone Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Protein Modification By Small Protein Removal Histone Deacetylase Binding Circadian Rhythm BAT3 Complex Binding Localization Within Membrane Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Exosomal Secretion Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Cellular Response To Stress Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex
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