DESI1 and SMIM21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DESI1	SMIM21
Description		desumoylating isopeptidase 1	small integral membrane protein 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Membrane
	Molecular Function	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding	Protein Binding
	Biological Process	Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation
Pathways
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Chronotype ( 30696823) Rheumatoid arthritis (ACPA-negative) ( 24532677) Serum uric acid levels in response to allopurinol in gout ( 25676789) Tenofovir clearance in HIV infection ( 26148204)
Interacting Genes		32 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46	2 interacting genes: CFTR DESI1
Entrez ID		27351	284274
HPRD ID		18590	18769
Ensembl ID		ENSG00000100418	ENSG00000206026
Uniprot IDs		Q6ICB0	J3KSN8 Q3B7S5
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?		Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DeSUMOylase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Macromolecule Depalmitoylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Long-chain Fatty Acyl-CoA Hydrolase Activity Cellular Response To Forskolin Response To Forskolin Protein-containing Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Macromolecule Deacylation Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Protein Export From Nucleus Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking
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