DESI1 and ZBTB46

Number of citations of the paper that reports this interaction (PMID 22370726)
12

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		DESI1	ZBTB46
Gene Name		desumoylating isopeptidase 1	zinc finger and BTB domain containing 46
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus
	Molecular Function	Peptidase Activity Identical Protein Binding	Nucleic Acid Binding Metal Ion Binding
	Biological Process	Proteolysis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: FGF7 ZBTB46	1 interactors: DESI1
Entrez ID		27351	140685
HPRD ID		18590	16567
Ensembl ID		ENSG00000100418	ENSG00000130584
Uniprot IDs		Q6ICB0	Q6ZMU8 Q86UZ6
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dendritic Cell Differentiation Secretion By Lung Epithelial Cell Involved In Lung Growth Positive Regulation Of Keratinocyte Migration Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Monocyte Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Keratinocyte Proliferation Lung Growth Negative Regulation Of Granulocyte Differentiation Regulation Of Dendritic Cell Differentiation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Macrophage Differentiation Regulation Of Monocyte Differentiation Mesenchymal-epithelial Cell Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis Mesenchymal Cell Proliferation Protein Localization To Cell Surface Regulation Of Keratinocyte Proliferation Positive Chemotaxis Branching Involved In Salivary Gland Morphogenesis Hair Follicle Morphogenesis Regulation Of Immune System Process Epidermis Morphogenesis Salivary Gland Morphogenesis Salivary Gland Development Negative Regulation Of Myeloid Leukocyte Differentiation Skin Morphogenesis Exocrine System Development Regulation Of Morphogenesis Of A Branching Structure Actin Cytoskeleton Reorganization Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Myeloid Cell Differentiation Stem Cell Proliferation Hair Follicle Development Hair Cycle Process Organ Growth Hair Cycle Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cell Division Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Migration Insulin Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Gland Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Myeloid Cell Differentiation
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