DESI1 and NT5C3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DESI1	NT5C3A
Description		desumoylating isopeptidase 1	5'-nucleotidase, cytosolic IIIA
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Nuclear Body
	Molecular Function	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding	Nucleotide Binding TRNA 2'-phosphotransferase Activity Magnesium Ion Binding Protein Binding 5'-nucleotidase Activity Transferase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation	Pyrimidine Nucleoside Metabolic Process Nucleotide Metabolic Process Defense Response To Virus
Pathways
Drugs
Diseases			Anemia due to disorders of nucleotide metabolism, including: Adenylate kinase (AK) deficiency; Uridine 5-prime monophosphate hydrolase (UMPH1) deficiency
GWAS		General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Estimated glomerular filtration rate ( 31152163) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		32 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46	6 interacting genes: DESI1 GNAQ NDUFAB1 UBQLN1 UBQLN2 VANGL1
Entrez ID		27351	51251
HPRD ID		18590	05871
Ensembl ID		ENSG00000100418	ENSG00000122643
Uniprot IDs		Q6ICB0	A0A090N7U2 Q9H0P0 X6RM59
PDB IDs		3EBQ	2CN1 2JGA 2VKQ
Enriched GO Terms of Interacting Partners?		Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle	Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Acyl Carrier Activity Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Acyl Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Mitochondrial Large Ribosomal Subunit Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Mitochondrial [2Fe-2S] Assembly Complex Protein Lipoylation Negative Regulation Of Clathrin-dependent Endocytosis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Vacuole Organization Protein Metabolic Process Regulation Of Macroautophagy DeSUMOylase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Phospholipase C-activating Serotonin Receptor Signaling Pathway [2Fe-2S] Cluster Assembly Mannosyltransferase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Response To Endoplasmic Reticulum Stress Mucociliary Clearance Iron-sulfur Cluster Assembly Complex Macromolecule Depalmitoylation Regulation Of Toll-like Receptor 3 Signaling Pathway Phototransduction, Visible Light Long-chain Fatty Acyl-CoA Hydrolase Activity Aggrephagy Autophagy G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Receptor Internalization Guanyl Nucleotide Binding Regulation Of Clathrin-dependent Endocytosis
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