ARRDC3 and FAM90A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARRDC3	FAM90A1
Description		arrestin domain containing 3	family with sequence similarity 90 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane Membrane
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Protein Binding
	Biological Process	Temperature Homeostasis Protein Transport Heat Generation Negative Regulation Of Heat Generation Positive Regulation Of Hippo Signaling Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 25038754 29059683) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)	Gut microbiota (functional units) ( 27694959)
Interacting Genes		36 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 FAM90A1 HPGDS ITCH MAGI2 MORF4L1 OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWP2 ZRANB1	162 interacting genes: ABI2 ACTN3 AKAP9 AMOTL2 ANKRD23 ANKRD29 AP2M1 APP ARHGEF9 ARRDC3 BANP BCAR1 BEGAIN BLZF1 CADPS CALCOCO2 CARD9 CCDC13 CCDC57 CCN3 CCNC CCNL2 CDR2 CEP55 CEP70 CEP72 CEP76 CHRDL2 COG6 CYSRT1 DTX3 DVL2 DVL3 EFEMP2 ENKD1 EXOSC8 FAM228A FHL3 FLACC1 FLOT1 FOSB FSD2 FXR1 FXR2 FYN GABPB1 GCSAML GNPTAB GOLGA2 GOPC GPRASP3 GPSM1 GRIPAP1 HAND2 HMBOX1 HOMER3 HOMEZ HOOK2 HSF2BP ISY1 KANK2 KASH5 KIFC3 KLHL12 KPNA6 KRT31 KRT34 KRT38 KRT40 KRTAP1-1 KRTAP10-8 LDOC1 LHX6 LIMS1 LMO2 LNX1 LRP2BP LRRK2 LZTS1 LZTS2 MAD1L1 MDFI MEIS3 MID2 MIPOL1 MLH1 MORN3 MSS51 MTUS2 MYOG NBPF19 NDUFB7 NOTCH2NLA NUDT21 OVOL1 PBX1 PBX2 PDLIM7 PFDN5 PICK1 PIH1D1 PLAGL2 POF1B PPARA PPP1R13B PRDM6 PRKAR1B PRR23B PSME3 PSTPIP1 RAB11FIP2 RABEP1 RBM48 REL RHOH RINT1 ROPN1 RPRD1A SH2B2 SIAH1 SMAD3 SMARCB1 SNW1 SPRED1 SRPK2 STAC3 STMN2 STX11 TAX1BP1 TEPSIN TFIP11 TLE5 TMCC2 TRAF2 TRAF4 TRIB3 TRIM23 TRIM27 TRIM42 TRIM54 TRIM55 TRIM69 TRIM9 TRIML2 VRTN VWC2 ZBTB14 ZBTB16 ZBTB7B ZBTB8A ZC2HC1C ZMYND12 ZNF143 ZNF212 ZNF343 ZNF526 ZNF581 ZNF655 ZNF688 ZNF76 ZRANB1 ZWINT
Entrez ID		57561	55138
HPRD ID		09810	07672
Ensembl ID		ENSG00000113369	ENSG00000171847
Uniprot IDs		Q96B67	Q86YD7
PDB IDs		4N7H 4R7V 4R7X
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding Protein Modification Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Autophagy Negative Regulation Of Signal Transduction Cytosol Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Monoubiquitination Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Protein Autoubiquitination Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Endosome Negative Regulation Of Intracellular Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Proteolysis Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Gene Expression Nucleoplasm Regulation Of Germinal Center Formation Cytoplasm Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Nucleus Regulation Of Protein Modification Process Catabolic Process Negative Regulation Of Endocytosis Positive Regulation Of Autophagy Receptor-mediated Endocytosis Regulation Of Signal Transduction Tolerance Induction Cellular Response To Unfolded Protein	Protein Binding Identical Protein Binding Zinc Ion Binding Cytoplasm Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Organelle Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction TORC1 Complex Assembly Cytoskeleton Signaling Adaptor Activity Protein Homodimerization Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Ubiquitination Keratin Filament Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding
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