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LSM3 and XPC
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
HPRD
(two hybrid)
LSM3
XPC
Description
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
XPC complex subunit, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Spliceosomal Complex
U6 SnRNP
Cytosol
U4/U6 X U5 Tri-snRNP Complex
U2-type Precatalytic Spliceosome
Precatalytic Spliceosome
Catalytic Step 2 Spliceosome
Lsm2-8 Complex
Lsm1-7-Pat1 Complex
Ribonucleoprotein Complex
Nucleotide-excision Repair Complex
Nucleotide-excision Repair Factor 2 Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
XPC Complex
Site Of DNA Damage
Molecular Function
RNA Binding
Protein Binding
U6 SnRNA 3'-end Binding
Heteroduplex DNA Loop Binding
Bubble DNA Binding
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Protein-containing Complex Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Damage Sensor Activity
Biological Process
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
P-body Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Response To UV-B
Response To Auditory Stimulus
Mitotic Intra-S DNA Damage Checkpoint Signaling
Positive Regulation Of DNA-templated Transcription
UV-damage Excision Repair
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
mRNA decay by 5' to 3' exoribonuclease
mRNA decay by 5' to 3' exoribonuclease
mRNA Splicing - Major Pathway
SUMOylation of DNA damage response and repair proteins
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Chronotype (
30696823
)
Dilated cardiomyopathy (
33677556
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Offspring birth weight (
31043758
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
45 interacting genes:
CCND3
CDKN2D
CEP95
CNOT7
DDIT4L
DLX4
EEF1A1
EIF4EBP2
EIF4G3
EXOSC1
EXOSC5
GDF9
GSTA1
HSPB1
INCA1
KEAP1
KLF3
LSM1
LSM10
LSM12
LSM2
LSM5
LSM6
LSM7
LSM8
NACC1
PIAS1
QKI
SF3B2
SH3GLB2
SMN1
SNRPD3
SNRPE
SNRPF
SNRPG
TCL1A
TEPSIN
THOC5
TRAPPC2B
UTP14A
WDR77
WDR83
XPC
XRN2
YBX1
17 interacting genes:
BTG3
CETN2
DDB2
ERCC3
GTF2H1
LSM3
MDM2
PSMC5
PSMD4
RAD23A
RAD23B
RPA1
SMAD1
TDG
USP7
XPA
ZNF512B
Entrez ID
27258
7508
HPRD ID
06283
02046
Ensembl ID
ENSG00000170860
ENSG00000154767
Uniprot IDs
P62310
Q01831
X5DRB1
PDB IDs
3JCR
5O9Z
6AH0
6AHD
6QW6
6QX9
7ABG
8H6E
8H6J
8H6K
8H6L
8QO9
8QXD
8QZS
8R08
8R09
8R0A
8R0B
8RM5
2A4J
2GGM
2OBH
2RVB
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
Enriched GO Terms of Interacting Partners
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RNA Splicing
MRNA Metabolic Process
MRNA Processing
U2-type Precatalytic Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Processing
U4/U6 X U5 Tri-snRNP Complex
RNA Binding
MRNA Splicing, Via Spliceosome
U12-type Spliceosomal Complex
RNA Metabolic Process
Spliceosomal Complex
Nucleic Acid Metabolic Process
U7 SnRNP
Lsm2-8 Complex
Precatalytic Spliceosome
U6 SnRNP
Spliceosomal SnRNP Assembly
Catalytic Step 2 Spliceosome
Nucleoplasm
Methylosome
Ribonucleoprotein Complex
Lsm1-7-Pat1 Complex
Nucleobase-containing Compound Metabolic Process
Small Nuclear Ribonucleoprotein Complex
SMN-Sm Protein Complex
Nucleus
MRNA Catabolic Process
RNA Catabolic Process
Spliceosomal Complex Assembly
7-methylguanosine Cap Hypermethylation
U2-type Prespliceosome Assembly
U2 SnRNP
U2-type Spliceosomal Complex
U4 SnRNP
Protein-RNA Complex Assembly
Cytoplasm
Macromolecule Metabolic Process
U1 SnRNP
U5 SnRNP
Nucleobase-containing Compound Catabolic Process
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
U2-type Catalytic Step 2 Spliceosome
U6 SnRNA Binding
P-body
RNA Exonuclease Activity
Nuclear-transcribed MRNA Catabolic Process
Cytosol
U7 SnRNA Binding
Nucleotide-excision Repair
Damaged DNA Binding
DNA Repair
DNA Damage Response
DNA Metabolic Process
Nucleoplasm
Cellular Response To Stress
Nucleic Acid Metabolic Process
Macromolecule Metabolic Process
Proteasome Complex
Nucleus
Nucleobase-containing Compound Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
XPC Complex
Base-excision Repair
Polyubiquitin Modification-dependent Protein Binding
Response To Stress
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To UV
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
UV-damage Excision Repair
UV Protection
Transcription Factor TFIIH Core Complex
Transcription-coupled Nucleotide-excision Repair
Proteasome Regulatory Particle, Base Subcomplex
Transcription Factor TFIIH Holo Complex
DNA Replication Factor A Complex
Cellular Response To UV
Proteasomal Protein Catabolic Process
Proteasome Accessory Complex
Ubiquitin Binding
Proteasome Binding
Cellular Response To Light Stimulus
Single-stranded DNA Binding
PML Body
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Light Stimulus
Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Cellular Response To Radiation
Site Of DNA Damage
Response To Radiation
Protein-containing Complex
Nucleotide-excision Repair Factor 3 Complex
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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