LSM3 and SF3B2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		LSM3	SF3B2
Gene Name		LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	splicing factor 3b, subunit 2, 145kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Catalytic Step 2 Spliceosome	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome MRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Viral Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		28 interactors: CEP95 CLNS1A DLX4 EEF1A1 GDF9 GSTA1 KEAP1 LSM1 LSM10 LSM2 LSM5 LSM6 LSM7 LSM8 SF3B2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPG TCL1A THOC5 UTP14A WDR77 WDR83 XPC XRN2 YBX1	25 interactors: APBB1 APP C7orf25 C8orf33 CSNK2A1 ERG FRA10AC1 HNRNPC KDM1A KIAA0368 LSM2 LSM3 PCBP2 PRPF40A RBM7 RBM8A SF3B4 SMAD3 SNRNP200 TCERG1 THOC1 TOE1 TTC14 U2AF1 ZCCHC10
Entrez ID		27258	10992
HPRD ID		06283	10410
Ensembl ID			ENSG00000087365
Uniprot IDs		P62310	Q13435
PDB IDs			2DO5
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Metabolic Process Ribonucleoprotein Complex Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Ribonucleoprotein Complex Assembly NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay DNA-templated Transcription, Termination RNA Catabolic Process Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Spliceosomal Complex Assembly MRNA Catabolic Process MRNA 3'-end Processing Cellular Macromolecule Catabolic Process Cellular Macromolecular Complex Assembly RNA 3'-end Processing Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Process Catabolic Process Maturation Of SSU-rRNA Transcription, DNA-templated RNA Biosynthetic Process Ribosomal Small Subunit Biogenesis Oocyte Growth Nucleotide-excision Repair, DNA Damage Recognition Cellular Component Assembly Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Progesterone Secretion Proteasomal Ubiquitin-independent Protein Catabolic Process CRD-mediated MRNA Stabilization	RNA Processing MRNA Processing RNA Splicing MRNA Metabolic Process RNA Metabolic Process Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process MRNA Export From Nucleus Transcription, DNA-templated RNA Export From Nucleus RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of Cell Cycle RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus Osteoblast Differentiation RNA Transport Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Cycle RNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Catabolic Process Metabolic Process Termination Of RNA Polymerase II Transcription Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Negative Regulation Of Protein Metabolic Process Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Negative Regulation Of Potassium Ion Export Negative Regulation Of Isotype Switching To IgA Isotypes
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