LSM3 and CNOT7

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		LSM3	CNOT7
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	CCR4-NOT transcription complex subunit 7
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Translation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1	29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI OBI1 PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101
Entrez ID		27258	29883
HPRD ID		06283	05370
Ensembl ID		ENSG00000170860	ENSG00000198791
Uniprot IDs		P62310	Q96IQ6 Q9UIV1
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	2D5R 4GMJ 7AX1 7VOI
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding	Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Histone Kinase Activity Proteasome-activating Activity Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phorbol 13-acetate 12-myristate Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm CCR4-NOT Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?