PPA2 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		PPA2	VKORC1
Description		inorganic pyrophosphatase 2	vitamin K epoxide reductase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Regulation Of Mitochondrial Membrane Potential Diphosphate Metabolic Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways		Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Number of sexual partners ( 30643258) Regular attendance at a religious group ( 29970889) Response to antipsychotic treatment ( 23241943) Risk-taking tendency (4-domain principal component model) ( 30643258)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		2 interacting genes: TRIM63 VKORC1	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		27068	79001
HPRD ID		18494	10540
Ensembl ID		ENSG00000138777	ENSG00000167397
Uniprot IDs		Q9H2U2	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs			6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		U6 2'-O-snRNA Methylation Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Box C/D Sno(s)RNA 3'-end Processing Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Skeletal Muscle Atrophy SnRNA Modification Skeletal Muscle Adaptation Striated Muscle Atrophy 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Quinone Binding Muscle Atrophy U6 SnRNA Binding Vitamin K Metabolic Process Titin Binding Contractile Muscle Fiber Peptidyl-glutamic Acid Modification Negative Regulation Of Viral Transcription Sno(s)RNA Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II M Band Negative Regulation Of ATP Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Coagulation SnRNA Processing Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy SnRNA Metabolic Process Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Bone Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Viral Process Regulation Of ATP Metabolic Process RNA Methylation RNA 3'-end Processing Response To Interleukin-1 Regulation Of Purine Nucleotide Metabolic Process Ketone Metabolic Process	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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