PPA2

Description		inorganic pyrophosphatase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Synapse
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Regulation Of Mitochondrial Membrane Potential Diphosphate Metabolic Process
Pathways		Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis
Drugs
Diseases
GWAS		Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Number of sexual partners ( 30643258) Regular attendance at a religious group ( 29970889) Response to antipsychotic treatment ( 23241943) Risk-taking tendency (4-domain principal component model) ( 30643258)
Novel Interacting Genes		1 novel interacting genes: LARP7
Interacting Genes		2 interacting genes: TRIM63 VKORC1
Entrez ID		27068
HPRD ID		18494
Ensembl ID		ENSG00000138777
Uniprot IDs		Q9H2U2
PDB IDs
Enriched GO Terms of Interacting Partners?		U6 2'-O-snRNA Methylation Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Box C/D Sno(s)RNA 3'-end Processing Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Skeletal Muscle Atrophy SnRNA Modification Skeletal Muscle Adaptation Striated Muscle Atrophy 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Quinone Binding Muscle Atrophy U6 SnRNA Binding Vitamin K Metabolic Process Titin Binding Contractile Muscle Fiber Peptidyl-glutamic Acid Modification Negative Regulation Of Viral Transcription Sno(s)RNA Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II M Band Negative Regulation Of ATP Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Coagulation SnRNA Processing Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy SnRNA Metabolic Process Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Bone Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Viral Process Regulation Of ATP Metabolic Process RNA Methylation RNA 3'-end Processing Response To Interleukin-1 Regulation Of Purine Nucleotide Metabolic Process Ketone Metabolic Process
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