CD3G and TRB

Number of citations of the paper that reports this interaction (PubMedID 2138083)
0

Data Source:
HPRD (in vivo)

		CD3G	TRB
Description		CD3 gamma subunit of T-cell receptor complex	T cell receptor beta locus
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding	Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process	Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Surface Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS			Narcolepsy ( 24204295)
Interacting Genes		14 interacting genes: CATSPERH CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD	14 interacting genes: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 TAF1B TRA TRAT1 TRD
Entrez ID		917	6957
HPRD ID		07037	01739
Ensembl ID		ENSG00000160654
Uniprot IDs		B0YIY5 P09693
PDB IDs		1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin	Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Detection Of Biotic Stimulus Detection Of Bacterium T Cell Receptor Binding T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Gamma-delta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response External Side Of Plasma Membrane Antigen Processing And Presentation Of Endogenous Antigen T Cell Selection Regulation Of Immune Response Alpha-beta T Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Cytotoxicity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive T Cell Selection Immune Response-activating Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Immune Response-regulating Signaling Pathway Gamma-delta T Cell Activation Activation Of Immune Response Thymic T Cell Selection Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Detection Of Stimulus Regulation Of T Cell Mediated Immunity Lumenal Side Of Endoplasmic Reticulum Membrane TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains T Cell Activation Peptide Antigen Binding Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Antigen Protection From Natural Killer Cell Mediated Cytotoxicity Response To Bacterium Regulation Of T Cell Proliferation Immune Response To Tumor Cell
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