CD3G and CATSPERH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD3G	CATSPERH
Description		CD3 gamma subunit of T-cell receptor complex	catsper channel auxiliary subunit eta
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex	Plasma Membrane Cilium Membrane Motile Cilium CatSper Complex Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Muromonab Teclistamab Odronextamab
Diseases
GWAS
Interacting Genes		14 interacting genes: CATSPERH CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD	13 interacting genes: AQP6 CD3G CD79A EDA2R EMP1 FFAR2 GPR42 KLRC1 MANBAL PSCA SHISAL1 SLC10A6 UPK1B
Entrez ID		917	100130348
HPRD ID		07037
Ensembl ID		ENSG00000160654	ENSG00000187066
Uniprot IDs		B0YIY5 P09693	E9PQX1
PDB IDs		1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin	Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Nitrate Transmembrane Transporter Activity Inhibitory MHC Class Ib Receptor Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Adaptive Immune Response Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Gamma-delta T Cell Receptor Complex IgM B Cell Receptor Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Apical Plasma Membrane Urothelial Plaque External Side Of Plasma Membrane Plasma Membrane B Cell Receptor Complex Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Ectodermal Cell Differentiation Bile Acid:sodium Symporter Activity
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