FCGR2A and CRP

Number of citations of the paper that reports this interaction (PMID 10675363)
26

Data Source:
HPRD (in vivo)

		FCGR2A	CRP
Gene Name		Fc fragment of IgG, low affinity IIa, receptor (CD32)	C-reactive protein, pentraxin-related
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Filopodium Growth Cone Extracellular Vesicular Exosome
	Molecular Function	IgG Binding	Complement Component C1q Binding Calcium Ion Binding Protein Binding Cholesterol Binding Low-density Lipoprotein Particle Binding Choline Binding Protein Homodimerization Activity Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Response To Hypoxia Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Aging Opsonization Response To Lead Ion Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Wound Healing Response To Ethanol Negative Regulation Of Vasodilation Defense Response To Gram-positive Bacterium Protein Polymerization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Development Regulation Of Interleukin-8 Secretion
Pathways		Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs			Phosphocholine
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22081228) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 19915573 20228799 21297633)	C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 21300955 22939635) Inflammatory biomarkers ( 22291609) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Protein-Protein Interactions		13 interactors: BLK CRP CRYAB FYN GP6 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1	20 interactors: APCS C1QA CFH DGCR14 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 HIST1H1A HIST1H2AL HIST2H2AC LAMC3 LEP MAPK1 MAPK3 RPL13A SNRNP70
Entrez ID		2212	1401
HPRD ID		00906	00422
Ensembl ID		ENSG00000143226	ENSG00000132693
Uniprot IDs		P12318	P02741
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6	1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Regulation Of Immune Response Platelet Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Stress Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune System Process Wound Healing Immune System Process Positive Regulation Of Immune Response Cell Activation Response To Wounding Blood Coagulation Hemostasis Fc-epsilon Receptor Signaling Pathway Cell Migration Phagocytosis Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Autophosphorylation Locomotion Response To Peptide Hormone Cellular Response To Stimulus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Leukocyte Activation Response To Peptide Response To Hormone Movement Of Cell Or Subcellular Component Transcription Factor Import Into Nucleus Cellular Response To Hormone Stimulus	Immune System Process Innate Immune Response Immune Response Regulation Of Immune System Process Defense Response Regulation Of Golgi Inheritance Regulation Of Immune Response Positive Regulation Of Immune System Process Caveolin-mediated Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response JAK-STAT Cascade Regulation Of Golgi Organization Platelet Activation Response To Stress Regulation Of Early Endosome To Late Endosome Transport Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Cytokine Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Blood Coagulation Hemostasis Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Immune Response-regulating Signaling Pathway Response To Growth Hormone Response To Exogenous DsRNA Leukocyte Migration Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Apolipoprotein Binding Cellular Response To L-ascorbic Acid Toll-like Receptor 5 Signaling Pathway Viral Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
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