FCGR2A and UPK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCGR2A	UPK2
Description		Fc gamma receptor IIa	uroplakin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding IgG Receptor Activity IgG Binding	Protein Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis	Epithelial Cell Differentiation
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases		Systemic lupus erythematosus
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)	Asthma ( 31959851)
Interacting Genes		26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2	36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4
Entrez ID		2212	7379
HPRD ID		00906	10295
Ensembl ID		ENSG00000143226	ENSG00000110375
Uniprot IDs		A0A8V8TPS4 P12318	O00526
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity	Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin
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