MAP4K1 and DBNL

Number of citations of the paper that reports this interaction (PMID 10567356)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAP4K1	DBNL
Gene Name		mitogen-activated protein kinase kinase kinase kinase 1	drebrin-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Golgi Membrane Ruffle Podosome Cytoplasm Cytosol Plasma Membrane Cell Cortex Postsynaptic Density Lamellipodium Cell Junction Dendrite Clathrin-coated Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity	Actin Binding Protein Binding Protein C-terminus Binding Enzyme Activator Activity Protein Domain Specific Binding Actin Filament Binding
	Biological Process	Activation Of MAPKKK Activity Protein Phosphorylation Response To Stress Activation Of JUN Kinase Activity Cell Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Immune System Process Receptor-mediated Endocytosis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of JUN Kinase Activity Synapse Assembly Rac Protein Signal Transduction Neuron Projection Morphogenesis Podosome Assembly Ruffle Assembly
Pathways			Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ABL1 BLNK CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	12 interactors: ACD CASP3 LMNA MAP4K1 NEURL4 POT1 SH2D4A SH3BP2 SYK TERF1 TERF2IP ZAP70
Entrez ID		11184	28988
HPRD ID		03583	06588
Ensembl ID		ENSG00000104814	ENSG00000136279
Uniprot IDs		Q92918	B4DDU5 Q9UJU6
PDB IDs			1X67
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Immune System Process Regulation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of MAPK Cascade Regulation Of Immune Response Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Activation Immune Response Positive Regulation Of Protein Phosphorylation Defense Response Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Kinase Activity Platelet Activation Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process MAPK Cascade Cell Surface Receptor Signaling Pathway	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Beta Selection Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Catalytic Activity Telomere Assembly Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Transferase Activity Positive Regulation Of Telomerase Activity Regulation Of Cellular Component Organization Negative Regulation Of Telomerase Activity Positive Regulation Of Alpha-beta T Cell Proliferation Cellular Response To Stress Regulation Of DNA Replication Positive Regulation Of Catalytic Activity Regulation Of Organelle Organization Regulation Of T Cell Proliferation Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Localization To Organelle DNA Metabolic Process Positive Regulation Of Calcium-mediated Signaling Protein Localization To Chromosome Protein Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Activation Of JUN Kinase Activity T Cell Selection Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Differentiation Homeostatic Process DNA Replication Regulation Of Protein Kinase Activity Response To Stress Regulation Of T Cell Activation Negative Regulation Of Transferase Activity
Tagcloud ?		accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste	compound drebrin embryonic ic implied indispensable initiating intravenous invasiveness leucine library maintenance mammosphere maternal melk otssp167 pancreas possibly promising proteasome psma1 substrates successfully suppress suppression throughput upregulated xenograft zipper
Tagcloud (Difference) ?		accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste	compound drebrin embryonic ic implied indispensable initiating intravenous invasiveness leucine library maintenance mammosphere maternal melk otssp167 pancreas possibly promising proteasome psma1 substrates successfully suppress suppression throughput upregulated xenograft zipper
Tagcloud (Intersection) ?