MAP4K1 and H2AC4

Number of citations of the paper that reports this interaction (PubMedID 17895239)
0

Data Source:
BioGRID (enzymatic study)

		MAP4K1	H2AC4
Description		mitogen-activated protein kinase kinase kinase kinase 1	H2A clustered histone 4
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GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleosome Nucleus Chromosome CENP-A Containing Nucleosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate	Chromatin Organization Negative Regulation Of Cell Population Proliferation Heterochromatin Formation Protein Localization To CENP-A Containing Chromatin
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs		Fostamatinib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)
Interacting Genes		24 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 PPP2CA SHC1 STRN4 SYK TMEM101	49 interacting genes: ACE2 ANAPC11 BAP1 BARD1 BMI1 BRCA1 CDK1 CDK2 CHD4 COMMD4 CREBBP DTX3L EIF2AK2 EP300 EZH2 FANCD2 H2BC15 KAT2A KAT2B KAT5 KMT2A KMT2C KMT2D MAP4K1 MYB PCGF1 PRMT5 PSMD4 PTEN RAD18 RING1 RNF168 RNF169 RNF2 RNF20 RNF40 RNF8 RPL6 TP53BP1 TRIM37 TSPYL5 UBE2D3 UBE2N UFL1 UHRF1 USP16 USP2 USP22 USP51
Entrez ID		11184	8335
HPRD ID		03583	09105
Ensembl ID		ENSG00000104814	ENSG00000278463
Uniprot IDs		Q92918	P04908 Q08AJ9
PDB IDs		6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC 7L24 7L25 7L26 7M0K 7M0L 7M0M 7R9L 7R9N 7R9P 7R9T 7SIU 8CDW 8CIJ 8EEC 8FH4 8FJZ 8FKO 8PAR 8PAS 8PAU 8XN7 9BI8 9BIK 9BJ1 9CZT 9CZU 9CZW 9CZX 9D00 9H8D 9H8E 9H8F	2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6USJ 6V2K 6V92 6YOV 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7DBP 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7SCY 7SCZ 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7ZI4 8G57 8GRM 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HQY 8HR1 8I17 8IEG 8IEJ 8IHL 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8Q36 8Q3E 8Q3M 8Q3X 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8W9D 8W9E 8W9F 8WG5 8X7I 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 8YV8 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Signal Transduction Positive Regulation Of Immune Response Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Tyrosine Kinase Binding Lymphocyte Homeostasis Leukocyte Activation Regulation Of T Cell Activation Leukocyte Homeostasis Lymphocyte Activation Cell Activation Positive Regulation Of Cell Population Proliferation Homeostasis Of Number Of Cells Cytosol Positive Regulation Of Cell Adhesion SH2 Domain Binding Regulation Of Lymphocyte Activation Protein Domain Specific Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway	Chromatin Remodeling Chromatin Organization Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Transferase Activity Regulation Of Cell Cycle Chromatin Binding Nucleus DNA Repair Regulation Of Primary Metabolic Process DNA Damage Response Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Regulation Of Gene Expression Regulation Of Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Repair Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Transcription Coactivator Activity Histone Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of DNA Metabolic Process Protein Ubiquitination
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