NTRK3 and NELFB

Number of citations of the paper that reports this interaction (PubMedID 24034695)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NTRK3	NELFB
Description		neurotrophic receptor tyrosine kinase 3	negative elongation factor complex member B
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Receptor Complex Postsynaptic Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm NELF Complex
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Neurotrophin Binding	RNA Binding Protein Binding
	Biological Process	Neuron Migration Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Heart Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Myelination In Peripheral Nervous System Cell Differentiation Positive Regulation Of Cell Migration Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Animal Organ Development Neuron Fate Specification Axon Extension Involved In Regeneration Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation System Development Positive Regulation Of Positive Chemotaxis Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neural Precursor Cell Proliferation	Cell Population Proliferation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Negative Regulation Of Stem Cell Differentiation
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation NTRK3 as a dependence receptor
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases		Neuroblastoma
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	15 interacting genes: BRCA1 CEBPA CEBPE DENR ESR1 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFE NTRK3 RAD51 TPRX1
Entrez ID		4916	25920
HPRD ID		01870	10845
Ensembl ID		ENSG00000140538	ENSG00000188986
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	Q8WX92
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD	6GML 7PKS 7YCX 8JJ6 8RBX 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Neurotrophin TRKA Receptor Binding ERBB Signaling Pathway Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Nerve Growth Factor Signaling Pathway Response To Epidermal Growth Factor Glial Cell Development Schwann Cell Development Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Intracellular Signaling Cassette Insulin Receptor Binding Positive Regulation Of Defense Response ERBB2 Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Interleukin-34-mediated Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Interleukin-1-mediated Signaling Pathway Early Endosome Positive Regulation Of ERK1 And ERK2 Cascade Ephrin Receptor Binding Neurotrophin Signaling Pathway Cell Population Proliferation Cytosol Regulation Of Golgi Inheritance	Integrated Stress Response Signaling Chromatin Binding Chromatin Myeloid Cell Differentiation Response To Lipid RNA Polymerase II Transcription Regulator Complex Nucleoplasm Nuclear Ubiquitin Ligase Complex Myeloid Leukocyte Differentiation Transcription Factor AP-1 Complex Cellular Response To Oxygen-containing Compound Enzyme Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Steroid Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleus Protein-containing Complex Cellular Response To Lipid Lateral Element Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Tumor Necrosis Factor Response To Alcohol Response To Corticosterone Positive Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Response To Xenobiotic Stimulus Positive Regulation Of RNA Metabolic Process Response To Tumor Necrosis Factor Regulation Of DNA Damage Checkpoint Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Mononuclear Cell Differentiation Response To Glucocorticoid Response To Hormone Double-stranded DNA Binding Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Granulocyte Differentiation Nuclear Chromosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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