NTRK3 and SHC2

Number of citations of the paper that reports this interaction (PMID 12006576)
9

Data Source:
HPRD (two hybrid, in vivo)

		NTRK3	SHC2
Gene Name		neurotrophic tyrosine kinase, receptor, type 3	SHC (Src homology 2 domain containing) transforming protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex	Cellular_component Cytosol Plasma Membrane
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway Signal attenuation Signaling by VEGF Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Signalling to RAS SHC-mediated signalling Signaling by Insulin receptor
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1	8 interactors: EGFR ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3
Entrez ID		4916	25759
HPRD ID		01870	19296
Ensembl ID		ENSG00000140538	ENSG00000129946
Uniprot IDs		B7Z7U4 H0YND1 Q16288 Q96CY4	P98077
PDB IDs		1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity	Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Rhythmic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Signal Transduction Positive Regulation Of Cell Proliferation Cell Migration Phosphatidylinositol-mediated Signaling Cell Motility Regulation Of Signaling Cell Surface Receptor Signaling Pathway Phosphorylation Positive Regulation Of Protein Kinase Activity Circadian Rhythm Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Epithelium Development Regulation Of ERK1 And ERK2 Cascade Neuron Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	211h akt alternatively betabeta chemotaxis crosstalk erk erk1 fret irs knock knocking mek mesothelioma monitor msto obtain pdgf pdk1 phopho phospho pi3 rac1 raf rock ser473 sirnas sos thr308
Tagcloud (Intersection) ?