NTRK3 and DOK6

Number of citations: 37 (PubMedID 20565848)
Data Source: BioGRID (pull down)

		NTRK3	DOK6
Name		neurotrophic receptor tyrosine kinase 3	docking protein 6
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Receptor Complex Postsynaptic Membrane Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Neurotrophin Binding	Protein Binding
	Biological Process	Neuron Migration Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Heart Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Myelination In Peripheral Nervous System Cell Differentiation Positive Regulation Of Cell Migration Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Animal Organ Development Neuron Fate Specification Axon Extension Involved In Regeneration Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation System Development Positive Regulation Of Positive Chemotaxis Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neural Precursor Cell Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	RET signaling
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib	None
Diseases		Neuroblastoma	None
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Blood protein levels ( 30072576 ) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053 ) Gaucher disease severity ( 22388998 ) General risk tolerance (MTAG) ( 30643258 )	Bone fracture in osteoporosis ( 28580392 ) Caudate activity during reward ( 28927378 ) Mean platelet volume ( 31194788 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Osteoporosis-related phenotypes ( 20548944 ) Platelet distribution width ( 32888494 ) Pursuit maintenance gain ( 29064472 ) Response to cytidine analogues (gemcitabine) ( 24483146 ) Skin aging (microtopography measurement) ( 28502801 )
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	20 interacting genes: ABHD11 ARID5A C1orf94 CRYBB3 EGFR ERBB2 FAM86C1P LASP1 LGALS14 METTL27 NTRK3 PRR22 RBPMS RET RUSC1 SLC30A6 TBX15 TLE5 USP54 YPEL3
Entrez ID		4916	220164
HPRD ID		01870	13244
Ensembl ID		ENSG00000140538	ENSG00000206052
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	Q6PKX4
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD	Not available
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Neurotrophin TRKA Receptor Binding ERBB Signaling Pathway Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Nerve Growth Factor Signaling Pathway Response To Epidermal Growth Factor Glial Cell Development Schwann Cell Development Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Intracellular Signaling Cassette Insulin Receptor Binding Positive Regulation Of Defense Response ERBB2 Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Interleukin-34-mediated Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Interleukin-1-mediated Signaling Pathway Early Endosome Positive Regulation Of ERK1 And ERK2 Cascade Ephrin Receptor Binding Neurotrophin Signaling Pathway Cell Population Proliferation Cytosol Regulation Of Golgi Inheritance	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Receptor Complex