NTRK3 and KIDINS220

Number of citations of the paper that reports this interaction (PubMedID 15167895)
43

Data Source:
HPRD (in vivo)

		NTRK3	KIDINS220
Description		neurotrophic receptor tyrosine kinase 3	kinase D interacting substrate 220
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Receptor Complex Postsynaptic Membrane Glutamatergic Synapse	Endosome Late Endosome Cytosol Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Neurotrophin Binding	Protein Binding Protein Kinase Regulator Activity PDZ Domain Binding
	Biological Process	Neuron Migration Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Heart Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Myelination In Peripheral Nervous System Cell Differentiation Positive Regulation Of Cell Migration Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Animal Organ Development Neuron Fate Specification Axon Extension Involved In Regeneration Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation System Development Positive Regulation Of Positive Chemotaxis Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neural Precursor Cell Proliferation	In Utero Embryonic Development Nervous System Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	ARMS-mediated activation ARMS-mediated activation RND2 GTPase cycle RND1 GTPase cycle
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases		Neuroblastoma
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)	Alcoholic chronic pancreatitis ( 28754779) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	12 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 SEPTIN5
Entrez ID		4916	57498
HPRD ID		01870	17235
Ensembl ID		ENSG00000140538	ENSG00000134313
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	A0A8I5QJC0 Q9ULH0
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Neurotrophin TRKA Receptor Binding ERBB Signaling Pathway Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Nerve Growth Factor Signaling Pathway Response To Epidermal Growth Factor Glial Cell Development Schwann Cell Development Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Intracellular Signaling Cassette Insulin Receptor Binding Positive Regulation Of Defense Response ERBB2 Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Interleukin-34-mediated Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Interleukin-1-mediated Signaling Pathway Early Endosome Positive Regulation Of ERK1 And ERK2 Cascade Ephrin Receptor Binding Neurotrophin Signaling Pathway Cell Population Proliferation Cytosol Regulation Of Golgi Inheritance	Neurotrophin Binding Neurotrophin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Circadian Rhythm Cellular Developmental Process Positive Regulation Of Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Signal Transduction Response To Nerve Growth Factor Nerve Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Neuron Projection Development GPI-linked Ephrin Receptor Activity Positive Regulation Of Synapse Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Postsynaptic Specialization Assembly Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Action Potential Propagation Neuronal Action Potential Propagation Cell Death Programmed Cell Death Rhythmic Process B Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Nervous System Development System Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Positive Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization
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