NTRK3 and RASGRF1

Number of citations of the paper that reports this interaction (PMID 15513915)
15

Data Source:
HPRD (in vivo)

		NTRK3	RASGRF1
Gene Name		neurotrophic tyrosine kinase, receptor, type 3	Ras protein-specific guanine nucleotide-releasing factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex	Cytosol Plasma Membrane Growth Cone Neuron Projection
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding
	Biological Process	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Long-term Memory Cell Proliferation Neuron Projection Development Positive Regulation Of Ras GTPase Activity Activation Of Rac GTPase Activity Regulation Of Rac Protein Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)	Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1	16 interactors: ADRBK1 CEBPA EHD4 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 TNK2 USP8 YWHAB YWHAE
Entrez ID		4916	5923
HPRD ID		01870	07362
Ensembl ID		ENSG00000140538	ENSG00000058335
Uniprot IDs		B7Z7U4 H0YND1 Q16288 Q96CY4	A8K270 F8VPA5 J3KQP9 Q13972 Q8IUU5
PDB IDs		1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Locomotion Positive Regulation Of Protein Modification Process Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Ras Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Cell Migration Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cell Motility Signal Transduction Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Mechanoreceptor Differentiation Signaling Regulation Of Cell Death Positive Regulation Of Organelle Organization Cell Communication Protein Autophosphorylation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Differentiation Activation Of Protein Kinase Activity Defense Response
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Intersection) ?