NTRK3 and RASGRF1

Number of citations of the paper that reports this interaction (PubMedID 15513915)
0

Data Source:
HPRD (in vivo)

		NTRK3	RASGRF1
Description		neurotrophic receptor tyrosine kinase 3	Ras protein specific guanine nucleotide releasing factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Receptor Complex Postsynaptic Membrane Glutamatergic Synapse	Cytosol Plasma Membrane Growth Cone Neuron Projection
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Neurotrophin Binding	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding
	Biological Process	Neuron Migration Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Heart Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Myelination In Peripheral Nervous System Cell Differentiation Positive Regulation Of Cell Migration Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Animal Organ Development Neuron Fate Specification Axon Extension Involved In Regeneration Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation System Development Positive Regulation Of Positive Chemotaxis Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neural Precursor Cell Proliferation	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Long-term Memory Neuron Projection Development Response To Endoplasmic Reticulum Stress Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases		Neuroblastoma
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)	Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 20835236 23396134 32231278) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	20 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 STIP1 TNK2 USP8 YWHAB YWHAE
Entrez ID		4916	5923
HPRD ID		01870	07362
Ensembl ID		ENSG00000140538	ENSG00000058335
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	A8K270 Q13972 Q8IUU5
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Neurotrophin TRKA Receptor Binding ERBB Signaling Pathway Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Nerve Growth Factor Signaling Pathway Response To Epidermal Growth Factor Glial Cell Development Schwann Cell Development Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Intracellular Signaling Cassette Insulin Receptor Binding Positive Regulation Of Defense Response ERBB2 Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Interleukin-34-mediated Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Interleukin-1-mediated Signaling Pathway Early Endosome Positive Regulation Of ERK1 And ERK2 Cascade Ephrin Receptor Binding Neurotrophin Signaling Pathway Cell Population Proliferation Cytosol Regulation Of Golgi Inheritance	Intracellular Signaling Cassette Nucleotide Binding Neurotrophin Receptor Activity Neurotrophin Binding Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Signal Transduction Protein Kinase Activity Response To Growth Factor Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Kinase Activity Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Small GTPase-mediated Signal Transduction Neuron Migration Regulation Of Synapse Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Phosphorylation Mechanoreceptor Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Neurotrophin Signaling Pathway Protein Domain Specific Binding Focal Adhesion Positive Regulation Of Cell Junction Assembly Plasma Membrane Regulation Of Blood Circulation Regulation Of Neuron Apoptotic Process Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Phosphoprotein Binding Cell Motility Endosome Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication
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