BAP1 and PARP3

		BAP1	PARP3
Description		BRCA1 associated deubiquitinase 1	poly(ADP-ribose) polymerase family member 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Nuclear Body Site Of Double-strand Break Intercellular Bridge
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity	Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD DNA ADP-ribosyltransferase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Macromolecule Biosynthetic Process DNA ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Isotype Switching Negative Regulation Of DNA Metabolic Process Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs			2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		30 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	4 interacting genes: APP H1-1 MEOX2 PARP1
Entrez ID		8314	10039
HPRD ID		04366	06370
Ensembl ID		ENSG00000163930	ENSG00000041880
Uniprot IDs		F8W6N3 Q92560	Q9Y6F1
PDB IDs		7VPW 8H1T 8SVF	2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction	Chromatin Remodeling Regulation Of ATP Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Chromatin Organization NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Chromatin Binding NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Chromatin DNA Binding Nucleate Erythrocyte Differentiation Thrombocyte Differentiation DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Chromosome Myeloid Leukocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of ATP Biosynthetic Process NAD+-protein-serine ADP-ribosyltransferase Activity Negative Regulation Of DNA Metabolic Process Regulation Of Protein Localization To Nucleus Regulation Of DNA Recombination NAD DNA ADP-ribosyltransferase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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