RNF5 and SLC1A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RNF5	SLC1A1
Name		ring finger protein 5	solute carrier family 1 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Vesicle Asymmetric Synapse Neuron Projection Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Synapse Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Schaffer Collateral - CA1 Synapse Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Monoatomic Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Protein Destabilization ERAD Pathway Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly	Behavioral Fear Response Response To Amphetamine Regulation Of Heart Rate Glutathione Metabolic Process Glutathione Biosynthetic Process Superoxide Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Grooming Behavior Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Cellular Response To Oxidative Stress Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization Neuron Apoptotic Process L-glutamate Import Righting Reflex Retina Development In Camera-type Eye Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transmembrane Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Intracellular Glutamate Homeostasis Motor Neuron Apoptotic Process Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Cellular Response To Bisphenol A Conditioned Place Preference
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids
Drugs		None	Aspartic acid Glutamic acid
Diseases		None	Dicarboxylic aminoaciduria
GWAS		Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Idiopathic membranous nephropathy ( 21323541 ) Inflammatory bowel disease ( 28067908 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Prostate cancer ( 23535732 ) Soluble receptor for advanced glycation end-product levels ( 26083729 ) Ulcerative colitis ( 28067908 ) Waist circumference ( 31453325 ) Waist circumference variance ( 31453325 )	Coronary artery calcification ( 23870195 ) Metabolite levels ( 23823483 ) Pancreatic cancer ( 22158540 ) Response to antipsychotic treatment in schizophrenia ( 29503163 ) Response to risperidone in schizophrenia ( 29503163 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		54 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 EPHA2 EPHA3 EPHA4 FAM241B FHOD1 GLP1R INSIG2 JKAMP JMJD6 LEPROTL1 MPDZ MS4A1 ORMDL3 PGAM5 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		6048	6505
HPRD ID		04057	00597
Ensembl ID		ENSG00000204308	ENSG00000106688
Uniprot IDs		A0A024RCQ4 Q99942	P43005
PDB IDs		Not available	6S3Q 6X2L 6X2Z 6X3E 6X3F 7NSG 8CTC 8CTD 8CUA 8CUD 8CUI 8CUJ 8CV2 8CV3 9D66 9D67 9D68 9D69 9D6A
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination ATP Binding Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Binding Proteolysis Nucleotide Binding Protein K63-linked Ubiquitination Protein Metabolic Process Fasciculation Of Motor Neuron Axon Ephrin Receptor Activity Catabolic Process Membrane Positive Regulation Of Protein Polyubiquitination Fasciculation Of Sensory Neuron Axon UBC13-MMS2 Complex ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Cellular Response To Stress Endoplasmic Reticulum Membrane Regulation Of Protein Polyubiquitination Endosome Proteasomal Protein Catabolic Process ISG15-protein Conjugation Cholesterol Biosynthetic Process GPI-linked Ephrin Receptor Activity Positive Regulation Of Protein K63-linked Ubiquitination Golgi Trans Cisterna Sterol Biosynthetic Process Golgi Medial Cisterna Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Stress Fiber Assembly Protein Catabolic Process Endoplasmic Reticulum Regulation Of Protein K63-linked Ubiquitination	None