GH2 and GHR

Number of citations of the paper that reports this interaction (PMID 1955498)
1

Data Source:
HPRD (in vivo)

		GH2	GHR
Gene Name		growth hormone 2	growth hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Hormone Activity	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding
	Biological Process	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatropin recombinant Pegvisomant
Diseases
GWAS			Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		1 interactors: GHR	33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		2689	2690
HPRD ID		00750	02971
Ensembl ID		ENSG00000136487	ENSG00000112964
Uniprot IDs		P01242	P10912
PDB IDs			1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?		Activation Of JAK2 Kinase Activity Creatinine Metabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Taurine Metabolic Process Activation Of Janus Kinase Activity Valine Metabolic Process Creatine Metabolic Process Response To Cycloheximide Succinate Metabolic Process 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Insulin-like Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Growth Hormone Receptor Internalization Citrate Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Multicellular Organism Growth JAK-STAT Cascade Tricarboxylic Acid Metabolic Process Positive Regulation Of JAK-STAT Cascade Receptor Metabolic Process Multicellular Organismal Metabolic Process Regulation Of JAK-STAT Cascade Dicarboxylic Acid Metabolic Process Regulation Of Multicellular Organism Growth Response To Estradiol Activation Of MAPK Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Regulation Of Peptidyl-tyrosine Phosphorylation Response To Estrogen Positive Regulation Of MAP Kinase Activity Positive Regulation Of Growth Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Alpha-amino Acid Metabolic Process Regulation Of Developmental Growth Regulation Of MAP Kinase Activity Cellular Response To Peptide Hormone Stimulus Fatty Acid Metabolic Process	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		anadromous clock1alpha fishes foremost freshwater fshbeta ghr1 ghr2 mykiss ndk7 oncorhynchus parr precocious rainbow salmonid sc6a7 smolt smoltification smolts steelhead taldo1 thralpha thrbeta transformations tremendous trout undertake validates vdac2	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Difference) ?		anadromous clock1alpha fishes foremost freshwater fshbeta ghr1 ghr2 mykiss ndk7 oncorhynchus parr precocious rainbow salmonid sc6a7 smolt smoltification smolts steelhead taldo1 thralpha thrbeta transformations tremendous trout undertake validates vdac2	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Intersection) ?