GH2 and S100P

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		GH2	S100P
Description		growth hormone 2	S100 calcium binding protein P
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Endosome Lumen Vesicle	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Growth Hormone Receptor Binding Hormone Activity Growth Factor Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Response To Nutrient Levels Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway	Endothelial Cell Migration
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Neutrophil degranulation
Drugs			Cromoglicic acid
Diseases
GWAS		Height ( 31562340 33713608) Prudent dietary pattern ( 28644415) Waist circumference adjusted for body mass index ( 34021172)	Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: GHR S100A6 S100P	46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A
Entrez ID		2689	6286
HPRD ID		00750	02792
Ensembl ID		ENSG00000136487	ENSG00000163993
Uniprot IDs		A0A0M6L0J9 P01242	P25815
PDB IDs			1J55 1OZO 2MJW 7NMI
Enriched GO Terms of Interacting Partners?		Protein Homodimerization Activity Calcium-dependent Protein Binding Growth Hormone Receptor Activity Growth Hormone Receptor Complex Response To Growth Hormone Response To Cycloheximide Regulation Of Growth Hormone Receptor Signaling Pathway Response To Gravity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Extracellular Region Taurine Metabolic Process Identical Protein Binding Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Protein Tyrosine Kinase Activator Activity Proline-rich Region Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Calcium Ion Binding Transition Metal Ion Binding Growth Hormone Receptor Signaling Pathway Microvillus Membrane Response To Food Regulation Of Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT SH2 Domain Binding Peptide Hormone Binding Protein Tyrosine Kinase Binding Cytokine Binding Growth Factor Binding Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Fibroblast Proliferation	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation
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