TRIM10 and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 21143188)
0

Data Source:
BioGRID (two hybrid)

		TRIM10	UBE2D4
Description		tripartite motif containing 10	ubiquitin conjugating enzyme E2 D4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Erythrocyte Differentiation Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Interferon gamma signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) HIV-1 control ( 20041166) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neuroticism ( 29255261) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Tonsillitis ( 30037793)
Interacting Genes		19 interacting genes: CDK2 GEM HGS LNX1 PRKAB2 PSMA1 SCNM1 STING1 TRIM35 TRIM44 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 YPEL3 ZNF148 ZNF414 ZNF620	111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		10107	51619
HPRD ID		05752	14242
Ensembl ID		ENSG00000204613	ENSG00000078967
Uniprot IDs		A0A1U9X8M5 Q9UDY6	Q9Y2X8
PDB IDs		7QS0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Zinc Ion Binding Positive Regulation Of Defense Response To Virus By Host Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Defense Response To Virus By Host Cyclic-di-GMP Binding STING Complex Protein Modification Process Nucleus Proteolysis Nucleotide Binding Y Chromosome Positive Regulation Of Heterochromatin Formation Transferase Activity Metal Ion Binding Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Regulation Of Defense Response To Virus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Protein K48-linked Ubiquitination 2',3'-cyclic GMP-AMP Binding Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex ESCRT-0 Complex	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion
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