TRIM10 and ZNF148

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM10	ZNF148
Description		tripartite motif containing 10	zinc finger protein 148
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Erythrocyte Differentiation Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Defense Response Gamete Generation Negative Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) HIV-1 control ( 20041166) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neuroticism ( 29255261) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Tonsillitis ( 30037793)	Urate levels ( 31578528)
Interacting Genes		19 interacting genes: CDK2 GEM HGS LNX1 PRKAB2 PSMA1 SCNM1 STING1 TRIM35 TRIM44 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 YPEL3 ZNF148 ZNF414 ZNF620	25 interacting genes: CAVIN1 CEP63 CEP70 CLK1 DEUP1 EP300 GLRX3 GORASP2 JADE1 KRT31 KRT34 LNX1 LNX2 NUTM2F PFDN5 PLEKHG4 PNMA1 POU6F2 SIAH1 STAT3 TP53 TRIM10 UBC USP54 ZMYND12
Entrez ID		10107	7707
HPRD ID		05752	03540
Ensembl ID		ENSG00000204613	ENSG00000163848
Uniprot IDs		A0A1U9X8M5 Q9UDY6	Q9UQR1
PDB IDs		7QS0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Zinc Ion Binding Positive Regulation Of Defense Response To Virus By Host Macromolecule Catabolic Process Protein K11-linked Ubiquitination Regulation Of Defense Response To Virus By Host Cyclic-di-GMP Binding STING Complex Protein Modification Process Nucleus Proteolysis Nucleotide Binding Y Chromosome Positive Regulation Of Heterochromatin Formation Transferase Activity Metal Ion Binding Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Regulation Of Defense Response To Virus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Protein K48-linked Ubiquitination 2',3'-cyclic GMP-AMP Binding Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex ESCRT-0 Complex	T Cell Lineage Commitment De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Negative Regulation Of MiRNA Processing Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment System Development Organelle Organization Histone Acetyltransferase Complex CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Organelle Assembly Alpha-beta T Cell Lineage Commitment Identical Protein Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing RRNA Transcription Centriole Replication Centriole Assembly Regulation Of Generation Of Precursor Metabolites And Energy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Peptidyl-lysine Propionylation Nervous System Development Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cell Differentiation Cellular Component Assembly
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