CUL2 and MKNK2

Number of citations of the paper that reports this interaction (PMID 16856496)
0

Data Source:
BioGRID (two hybrid)

		CUL2	MKNK2
Gene Name		cullin 2	MAP kinase interacting serine/threonine kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D1 DCUN1D4 GPS1 KAT2A MKNK2 NEDD8 PRAME RNF7 SAP130 SENP8 TCEB1 UBE2D1 VHL ZER1 ZYG11B	11 interactors: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 RBX1 RPL7A VBP1
Entrez ID		8453	2872
HPRD ID		06786	05459
Ensembl ID		ENSG00000108094	ENSG00000099875
Uniprot IDs		Q13617	B3KS07 Q9HBH9
PDB IDs			2AC3 2AC5 2HW7
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Protein Deneddylation Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Modification By Small Protein Removal Protein Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cullin Deneddylation Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Proteolysis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Histone H3 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Catabolic Process Transcription, DNA-templated Response To Hypoxia RNA Biosynthetic Process SCF Complex Assembly Regulation Of Cellular Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Exosomal Secretion Protein Deubiquitination Histone Acetylation	Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Lipid Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Hormone Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 4 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Toll-like Receptor Signaling Pathway Vagina Development Uterus Development Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Response To Lipid Cellular Macromolecule Catabolic Process Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Intracellular Estrogen Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Activation Of Innate Immune Response Response To Hormone Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Insulin Receptor Signaling Pathway Female Genitalia Development Mammary Gland Epithelial Cell Proliferation Apoptotic Process Cellular Response To Lipopolysaccharide Signal Transduction MRNA Catabolic Process Cellular Response To Molecule Of Bacterial Origin Response To Peptide Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Death Nuclear-transcribed MRNA Poly(A) Tail Shortening Death
Tagcloud ?		adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von	2b 4g au characterised comprise dfd dfg differ eif4e export importin inserts integrating lacks map mknk1 mnk mnk1a mnk2a mnks mrnas polybasic possesses scaffold share subcellular symbols termini unusual
Tagcloud (Difference) ?		adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von	2b 4g au characterised comprise dfd dfg differ eif4e export importin inserts integrating lacks map mknk1 mnk mnk1a mnk2a mnks mrnas polybasic possesses scaffold share subcellular symbols termini unusual
Tagcloud (Intersection) ?