CUL2 and CAND1

Number of citations of the paper that reports this interaction (PubMedID 12609982)
0

Data Source:
HPRD (in vivo)

		CUL2	CAND1
Description		cullin 2	cullin associated and neddylation dissociated 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Protein Binding TBP-class Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Neutrophil degranulation Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B	20 interacting genes: CA9 CEBPA CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D2 DCUN1D4 DCUN1D5 DUX4 FILNC1 HSPA13 MTNR1A RBX1 RNF10 SKP1 SRPK2 UBE2M
Entrez ID		8453	55832
HPRD ID		06786	06983
Ensembl ID		ENSG00000108094	ENSG00000111530
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	Q86VP6
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH	1U6G 4A0C 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CDJ 8CDK 8H3Q 8OR0 8OR2 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Cullin Family Protein Binding G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification Process Protein Monoubiquitination Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Cul4A-RING E3 Ubiquitin Ligase Complex Proteolysis Involved In Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Protein Neddylation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Binding Cul7-RING Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Protein Polyubiquitination Regulation Of Cell Cycle Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Epithelial Cell Apoptotic Process Type I Interferon-mediated Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle
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