CUL2 and SAP130

Number of citations of the paper that reports this interaction (PMID 18173839)
8

Data Source:
BioGRID (pull down)

		CUL2	SAP130
Gene Name		cullin 2	Sin3A-associated protein, 130kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleoplasm STAGA Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Transcription Coactivator Activity Histone Acetyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Gene Expression Regulation Of Gene Expression, Epigenetic Histone H3 Acetylation Negative Regulation Of Gene Expression, Epigenetic
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System	NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D1 DCUN1D4 GPS1 KAT2A MKNK2 NEDD8 PRAME RNF7 SAP130 SENP8 TCEB1 UBE2D1 VHL ZER1 ZYG11B	5 interactors: ARID4B CSN1S1 CUL2 MYC SMAD3
Entrez ID		8453	79595
HPRD ID		06786	18015
Ensembl ID		ENSG00000108094	ENSG00000136715
Uniprot IDs		Q13617	Q9H0E3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Protein Deneddylation Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Modification By Small Protein Removal Protein Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cullin Deneddylation Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Proteolysis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Histone H3 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Catabolic Process Transcription, DNA-templated Response To Hypoxia RNA Biosynthetic Process SCF Complex Assembly Regulation Of Cellular Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Exosomal Secretion Protein Deubiquitination Histone Acetylation	Cell Cycle Arrest Negative Regulation Of Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Cell Proliferation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Cysteine-type Endopeptidase Activity Mesonephros Development Positive Regulation Of Endopeptidase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Fibroblast Apoptotic Process Kidney Epithelium Development Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cell Cycle Evasion Or Tolerance Of Host Defenses By Virus Response To Transforming Growth Factor Beta Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Cell Cycle Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Cell Death Death Epithelium Development DNA-templated Transcription, Initiation Response To Abiotic Stimulus Regulation Of Extracellular Matrix Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Establishment Of Sertoli Cell Barrier Primary MiRNA Processing Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Response To Hypoxia SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Histone H4-K20 Trimethylation Negative Regulation Of Gene Expression
Tagcloud ?		adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von	clearance closure comprehensively dedifferentiate drastic edge enable fluorescently healing kismet mip120 modifying motile osa partly periphery practical publicly pvr reporter reporters repressed sin3a spt6 tagged tagging thirteen underlie wound
Tagcloud (Difference) ?		adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von	clearance closure comprehensively dedifferentiate drastic edge enable fluorescently healing kismet mip120 modifying motile osa partly periphery practical publicly pvr reporter reporters repressed sin3a spt6 tagged tagging thirteen underlie wound
Tagcloud (Intersection) ?