CUL2 and KHNYN

Number of citations of the paper that reports this interaction (PubMedID 30659753)
0

Data Source:
BioGRID (pull down)

		CUL2	KHNYN
Description		cullin 2	KH and NYN domain containing
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Cellular_component Nucleus Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Molecular_function RNA Binding MRNA Binding RNA Endonuclease Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Biological_process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Appendicular lean mass ( 33097823)
Interacting Genes		28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B	5 interacting genes: CUL1 CUL2 PLOD3 TEPSIN UBC
Entrez ID		8453	23351
HPRD ID		06786	11076
Ensembl ID		ENSG00000108094	ENSG00000100441
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	A8K6L5 O15037
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH	2N5M 2N7K 8WZC 9BGL 9CS9 9HTS
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Ubiquitin Ligase Complex Scaffold Activity Modification-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Proteolysis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Coated Vesicle Membrane Ubiquitin-dependent Protein Catabolic Process Hydroxylysine Biosynthetic Process Protein Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Basement Membrane Assembly Procollagen Galactosyltransferase Activity Intrinsic Apoptotic Signaling Pathway Catabolic Process Epidermis Morphogenesis Protein-macromolecule Adaptor Activity Peptidyl-lysine Hydroxylation Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Endothelial Cell Morphogenesis Apoptotic Signaling Pathway Protein Tag Activity Protein Hydroxylation Cul2-RING Ubiquitin Ligase Complex L-ascorbic Acid Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Macromolecule Metabolic Process Small Molecule Binding Heart Valve Development
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