CUL2 and DCUN1D3

Number of citations of the paper that reports this interaction (PubMedID 28581483)
60

Data Source:
BioGRID (enzymatic study)

		CUL2	DCUN1D3
Description		cullin 2	defective in cullin neddylation 1 domain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Response To UV-C Response To Gamma Radiation Regulation Of Cell Cycle Process Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Protein Neddylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Neddylation Negative Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Neddylation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Hippocampal sclerosis ( 25188341)
Interacting Genes		28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B	3 interacting genes: CUL2 CUL3 UBE2M
Entrez ID		8453	123879
HPRD ID		06786	14660
Ensembl ID		ENSG00000108094	ENSG00000188215
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	Q8IWE4
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH	4GBA
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Ubiquitin Ligase Complex Scaffold Activity Cullin-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Trophectodermal Cellular Morphogenesis Intrinsic Apoptotic Signaling Pathway Liver Morphogenesis Cell Cycle Phase Transition NEDD8 Conjugating Enzyme Activity Regulation Protein Catabolic Process At Postsynapse Postsynapse POZ Domain Binding Protein Modification Process Polar Microtubule NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Embryonic Cleavage Fibroblast Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Proteasomal Protein Catabolic Process Negative Regulation Of Rho Protein Signal Transduction Renal Sodium Ion Transport Positive Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Notch Binding Modification-dependent Protein Catabolic Process Contractile Actin Filament Bundle Assembly Anaphase-promoting Complex-dependent Catabolic Process Stress Fiber Assembly Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Catabolic Process RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Glutamatergic Synapse Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Neddylation Stem Cell Division Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Gland Morphogenesis
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