FKBP6 and ALDH3A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FKBP6	ALDH3A1
Name		FKBP prolyl isomerase family member 6 (inactive)	aldehyde dehydrogenase 3 family member A1
Structure
GO Annotations	Cellular Component	Synaptonemal Complex Fibrillar Center Nucleus Cytoplasm Cytosol Microtubule Cytoskeleton Intercellular Bridge	Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Hsp90 Protein Binding	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Protein Folding Spermatogenesis Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Positive Regulation Of Viral Genome Replication Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated DNA Methylation	Aldehyde Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways		Meiotic synapsis PIWI-interacting RNA (piRNA) biogenesis	Phase I - Functionalization of compounds
Drugs		None	NADH
GWAS		Height ( 31562340 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood protein levels ( 30072576 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Refractive astigmatism ( 30306274 )
Interacting Genes		38 interacting genes: ACD ALDH3A1 CCDC198 CCNK CDK5RAP3 CFP CFTR CRACR2A DDIT4L DLGAP4 ECM1 EEF1D ENKD1 FAM107A GAPDH GSC2 HSP90AA1 IHO1 KANK2 KRT75 LZTS2 MAP3K1 MEI4 MEOX2 NME7 NTAQ1 PIAS2 PICK1 RAB11FIP2 RNF4 SAXO4 SUMO1P1 TEPSIN TINF2 TMEM9B TRIM55 TRIM63 ZNF655	5 interacting genes: FBXL12 FKBP6 POT1 SRF ZFTRAF1
Entrez ID		8468	218
HPRD ID		05326	00004
Ensembl ID		ENSG00000077800	ENSG00000108602
Uniprot IDs		O75344	I3L3I9 P30838 Q6PKA6
PDB IDs		3B7X	3SZA 3SZB 4H80 4L1O 4L2O 8BB8
GO Terms Enriched among Interactors		Shelterin Complex Telomere Assembly Meiotic DNA Double-strand Break Formation Protein Binding Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region	Serum Response Element Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Trachea Cartilage Development Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Positive Regulation Of Transcription By Glucose Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Primary MiRNA Binding Tangential Migration From The Subventricular Zone To The Olfactory Bulb Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Shelterin Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Negative Regulation Of Amyloid-beta Clearance Primitive Streak Formation Cardiac Muscle Cell Myoblast Differentiation FK506 Binding Telomeric Loop Disassembly G-rich Strand Telomeric DNA Binding Skin Morphogenesis Positive Thymic T Cell Selection Cardioblast Differentiation Transposable Element Silencing By PiRNA-mediated DNA Methylation Telomere Capping Heart Trabecula Formation Eyelid Development In Camera-type Eye Positive T Cell Selection Cardiac Myofibril Assembly Long-term Synaptic Depression Regulation Of DNA Strand Elongation Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly