APOBEC3F and RNF7

Number of citations: 89 (PubMedID 31253590)
Data Source: BioGRID (enzymatic study)

		APOBEC3F	RNF7
Name		apolipoprotein B mRNA editing enzyme catalytic subunit 3F	ring finger protein 7
Structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Copper Ion Binding Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Base Conversion Or Substitution Editing Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination Antiviral Innate Immune Response	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Reelin-mediated Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Phosphocreatine Biosynthetic Process Defense Response To Virus Response To Redox State Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways		None	Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
GWAS		No GWAS studies recorded	Hepatitis C induced liver fibrosis ( 22841784 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )
Novel Interactors		1 novel interactors: TYK2	None recorded
Interacting Genes		5 interacting genes: ACD APOBEC3G ARIH2 RNF7 TINF2	43 interacting genes: APOBEC3F APOBEC3G ARIH2 ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL5 CYCS ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBA3 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 USP40
Entrez ID		200316	9616
HPRD ID		16415	04840
Ensembl ID		ENSG00000128394	ENSG00000114125
Uniprot IDs		Q8IUX4	Q9UBF6
PDB IDs		3WUS 4IOU 4J4J 5HX4 5HX5 5W2M 5ZVA 5ZVB 6NIL	2ECL 7ONI
GO Terms Enriched among Interactors		Telomere Assembly Shelterin Complex Response To Virus Nuclear Telomere Cap Complex Protein Localization To Chromosome, Telomeric Region Telomere Capping Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of Telomere Maintenance Via Telomerase Growth Hormone Receptor Signaling Pathway Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Defense Response To Virus Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Other Organism Positive Regulation Of Telomere Maintenance Immune Response Negative Regulation Of Chromosome Organization DCTP Deaminase Activity Regulation Of DNA Biosynthetic Process Response To External Biotic Stimulus Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Perinucleolar Chromocenter Telomere Organization Negative Regulation Of DNA Metabolic Process Innate Immune Response Interleukin-12 Receptor Complex Negative Regulation Of Focal Adhesion Disassembly Negative Regulation Of Cellular Component Organization Interleukin-23 Receptor Complex NEDD8 Ligase Activity DNA Metabolic Process Defense Response To Symbiont Chromosome, Telomeric Region Defense Response To Other Organism Immune System Process NEDD8 Transferase Activity Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation Phosphocreatine Biosynthetic Process Apolipoprotein B MRNA Editing Enzyme Complex Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cullin-RING Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity Nucleus Cell Cycle Phase Transition Cul5-RING Ubiquitin Ligase Complex Protein K11-linked Ubiquitination Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition NEDD8 Transferase Activity Cytosol Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Virus Defense Response To Virus Intracellular Signal Transduction Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway NEDD8 Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Destabilization