FBXW8 and IRS1

Number of citations of the paper that reports this interaction (PMID 23045529)
1

Data Source:
BioGRID (pull down)

		FBXW8	IRS1
Gene Name		F-box and WD repeat domain containing 8	insulin receptor substrate 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Golgi Organization Cell Proliferation Protein Ubiquitination Positive Regulation Of Dendrite Morphogenesis Spongiotrophoblast Layer Development Labyrinthine Layer Blood Vessel Development	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs			[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Brain structure ( 22504417)	Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		6 interactors: CUL7 IRS1 MYC RBX1 SKP1 UBE2D3	73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		26259	3667
HPRD ID		16427	00943
Ensembl ID		ENSG00000174989	ENSG00000169047
Uniprot IDs		Q8N3Y1	P35568
PDB IDs			1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Notch Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Signal Transduction Positive Regulation Of Stem Cell Proliferation Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stress Viral Process Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Oxygen Levels Regulation Of Stem Cell Proliferation Response To Stress Cellular Response To Stimulus Fibroblast Apoptotic Process Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Catalytic Activity DNA-templated Transcription, Initiation Cell Cycle Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation
Tagcloud ?		2cells accumulated box cascade cd36 consists culiin1 cullin1 cyclin d1 e3 e3s endometrial fashion hec108 ligase moderately perk1 proteolysis rbx rbx1 ring scf skp1 sng ua ubiquitinated ubiquitination ursolic	action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin
Tagcloud (Difference) ?		2cells accumulated box cascade cd36 consists culiin1 cullin1 cyclin d1 e3 e3s endometrial fashion hec108 ligase moderately perk1 proteolysis rbx rbx1 ring scf skp1 sng ua ubiquitinated ubiquitination ursolic	action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin
Tagcloud (Intersection) ?