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FBXW8
Gene Name
F-box and WD repeat domain containing 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
3M Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Golgi Organization
Cell Proliferation
Protein Ubiquitination
Positive Regulation Of Dendrite Morphogenesis
Spongiotrophoblast Layer Development
Labyrinthine Layer Blood Vessel Development
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Brain structure (
22504417
)
Protein-protein Interactions
6 interactors:
CUL7
IRS1
MYC
RBX1
SKP1
UBE2D3
Entrez ID
26259
HPRD ID
16427
Ensembl ID
ENSG00000174989
Uniprot IDs
Q8N3Y1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Protein Monoubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Notch Signaling Pathway
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Mesenchymal Cell Proliferation
Regulation Of Mesenchymal Cell Proliferation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Signal Transduction
Positive Regulation Of Stem Cell Proliferation
Signaling
Cell Communication
Cell Surface Receptor Signaling Pathway
Cellular Response To Stress
Viral Process
Proteolysis
Positive Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Oxygen Levels
Regulation Of Stem Cell Proliferation
Response To Stress
Cellular Response To Stimulus
Fibroblast Apoptotic Process
Cellular Response To Organic Substance
Transforming Growth Factor Beta Receptor Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Catalytic Activity
DNA-templated Transcription, Initiation
Cell Cycle Process
Tagcloud
?
2cells
accumulated
box
cascade
cd36
consists
culiin1
cullin1
cyclin
d1
e3
e3s
endometrial
fashion
hec108
ligase
moderately
perk1
proteolysis
rbx
rbx1
ring
scf
skp1
sng
ua
ubiquitinated
ubiquitination
ursolic