FBXW8

Description		F-box and WD repeat domain containing 8
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centriole Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Cilium Assembly Labyrinthine Layer Blood Vessel Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Marginal zone lymphoma or rheumatoid arthritis ( 31407831) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Novel Interacting Genes		1 novel interacting genes: PBRM1
Interacting Genes		8 interacting genes: CUL1 CUL7 IRS1 MYC RBX1 SKP1 TRIB1 UBE2D3
Entrez ID		26259
HPRD ID		16427
Ensembl ID		ENSG00000174989
Uniprot IDs		Q8N3Y1
PDB IDs		7Z8B
Enriched GO Terms of Interacting Partners?		Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Monoubiquitination Cullin-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Epithelial Cell Apoptotic Process Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Insulin Receptor Signaling Pathway Protein Catabolic Process Protein Ubiquitination Regulation Of Cellular Response To Insulin Stimulus Proteolysis Insulin Receptor Signaling Pathway Protein Polyubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification By Small Protein Conjugation Post-translational Protein Modification Apoptotic Process Programmed Cell Death Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Family Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Catabolic Process Regulation Of Signal Transduction Transcription Elongation By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Myeloid Leukocyte Differentiation DNA-templated Transcription Elongation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
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