FBXW8 and CUL7

Number of citations of the paper that reports this interaction (PMID 10531037)
93

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FBXW8	CUL7
Gene Name		F-box and WD repeat domain containing 8	cullin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Golgi Organization Cell Proliferation Protein Ubiquitination Positive Regulation Of Dendrite Morphogenesis Spongiotrophoblast Layer Development Labyrinthine Layer Blood Vessel Development	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Dendrite Morphogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	IRE1alpha activates chaperones Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs
Diseases
GWAS		Brain structure ( 22504417)
Protein-Protein Interactions		6 interactors: CUL7 IRS1 MYC RBX1 SKP1 UBE2D3	7 interactors: COMMD1 FBXW8 MEGF10 PLXNB3 RBX1 SKP1 UBE2M
Entrez ID		26259	9820
HPRD ID		16427	09901
Ensembl ID		ENSG00000174989	ENSG00000044090
Uniprot IDs		Q8N3Y1	Q14999
PDB IDs			2JNG
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Notch Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Signal Transduction Positive Regulation Of Stem Cell Proliferation Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stress Viral Process Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Oxygen Levels Regulation Of Stem Cell Proliferation Response To Stress Cellular Response To Stimulus Fibroblast Apoptotic Process Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Catalytic Activity DNA-templated Transcription, Initiation Cell Cycle Process	Protein Neddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Activation Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Lamellipodium Assembly Regulation Of Protein Ubiquitination Negative Regulation Of Sodium Ion Transmembrane Transport Skeletal Muscle Satellite Cell Differentiation Recognition Of Apoptotic Cell Plasma Membrane To Endosome Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Cell Surface Histone H2A Monoubiquitination Negative Regulation Of Sodium Ion Transport Histone H2A Ubiquitination Phagocytosis, Recognition Regulation Of Protein Catabolic Process Spongiotrophoblast Layer Development
Tagcloud ?		2cells accumulated box cascade cd36 consists culiin1 cullin1 cyclin d1 e3 e3s endometrial fashion hec108 ligase moderately perk1 proteolysis rbx rbx1 ring scf skp1 sng ua ubiquitinated ubiquitination ursolic	112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Difference) ?		2cells accumulated box cascade cd36 consists culiin1 cullin1 cyclin d1 e3 e3s endometrial fashion hec108 ligase moderately perk1 proteolysis rbx rbx1 ring scf skp1 sng ua ubiquitinated ubiquitination ursolic	112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Intersection) ?