FBXW8 and CUL7

Number of citations of the paper that reports this interaction (PubMedID 10531037)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FBXW8	CUL7
Description		F-box and WD repeat domain containing 8	cullin 7
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centriole Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm 3M Complex	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Cilium Assembly Labyrinthine Layer Blood Vessel Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			3M syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Marginal zone lymphoma or rheumatoid arthritis ( 31407831) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Appendicular lean mass ( 33097823)
Interacting Genes		8 interacting genes: CUL1 CUL7 IRS1 MYC RBX1 SKP1 TRIB1 UBE2D3	10 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 TP53 UBE2M
Entrez ID		26259	9820
HPRD ID		16427	09901
Ensembl ID		ENSG00000174989	ENSG00000044090
Uniprot IDs		Q8N3Y1	A0A669KBH4 Q14999
PDB IDs		7Z8B	2JNG 7Z8B
Enriched GO Terms of Interacting Partners?		Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Monoubiquitination Cullin-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Epithelial Cell Apoptotic Process Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Insulin Receptor Signaling Pathway Protein Catabolic Process Protein Ubiquitination Regulation Of Cellular Response To Insulin Stimulus Proteolysis Insulin Receptor Signaling Pathway Protein Polyubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification By Small Protein Conjugation Post-translational Protein Modification Apoptotic Process Programmed Cell Death Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Family Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Catabolic Process Regulation Of Signal Transduction Transcription Elongation By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Myeloid Leukocyte Differentiation DNA-templated Transcription Elongation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation	Cul7-RING Ubiquitin Ligase Complex Nucleotide-excision Repair NEDD8 Transferase Activity SCF Ubiquitin Ligase Complex Negative Regulation Of Mitophagy Regulation Of Proteolysis Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Proteolysis Protein Neddylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cullin Family Protein Binding Molecular Function Activator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macroautophagy Copper Ion Binding Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Autophagy Of Mitochondrion Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Mitophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Import Interferon-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Neurogenesis Post-translational Protein Modification Apoptotic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Cellular Response To UV Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Catabolic Process Regulation Of Autophagy NEDD8 Conjugating Enzyme Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Insulin Receptor Signaling Pathway
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