FBXW8 and TRIB1

Number of citations of the paper that reports this interaction (PubMedID 34478796)
0

Data Source:
BioGRID (pull down)

		FBXW8	TRIB1
Description		F-box and WD repeat domain containing 8	tribbles pseudokinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centriole Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm 3M Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Enzyme Regulator Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Cilium Assembly Labyrinthine Layer Blood Vessel Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of JNK Cascade Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NGF-stimulated transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Marginal zone lymphoma or rheumatoid arthritis ( 31407831) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	A body shape index ( 34021172) Abdominal aortic aneurysm ( 32981348) Adiponectin levels ( 22479202) Adult body size ( 32376654) Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Birth weight ( 27680694 31043758) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol ( 31902109) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 26343387 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Fractures (paediatric) ( 32742401) Gamma glutamyl transferase levels ( 29403010 33339817) Glycated hemoglobin levels ( 34059833) Glycine levels ( 30837465 31070104) HDL cholesterol ( 20686565 24097068 25961943) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 27599772) Inflammatory bowel disease ( 23128233) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 19060911 20686565 20864672 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095) Liver enzyme levels (alanine transaminase) ( 22001757 33972514) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010 33339817) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Microalbuminuria ( 31511532) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387 33532862) Nonalcoholic fatty liver disease ( 31311600 34841290) Obesity-related traits ( 23251661) Percent liver fat ( 34128465) Response to statin therapy ( 20339536) Rosacea symptom severity ( 29771307) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total protein levels ( 29403010) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 29403010 33339817) Triglyceride levels ( 28334899 29403010 30698716 30911093 31647587 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 18193043 18193044 19060906 20139978 20686565 20864672 24097068 24886709 25961943 26582766 26780889) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 32499647) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count (basophil) ( 29403010)
Interacting Genes		8 interacting genes: CUL1 CUL7 IRS1 MYC RBX1 SKP1 TRIB1 UBE2D3	10 interacting genes: ACACA ALOX12 CEBPB CEBPD CEBPE FBXW8 KLC2 MAP2K1 MAP2K4 MAP2K7
Entrez ID		26259	10221
HPRD ID		16427	09863
Ensembl ID		ENSG00000174989	ENSG00000173334
Uniprot IDs		Q8N3Y1	Q96RU8
PDB IDs		7Z8B	5CEK 5CEM 5IGO 5IGQ 6DC0
Enriched GO Terms of Interacting Partners?		Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Monoubiquitination Cullin-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Epithelial Cell Apoptotic Process Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Insulin Receptor Signaling Pathway Protein Catabolic Process Protein Ubiquitination Regulation Of Cellular Response To Insulin Stimulus Proteolysis Insulin Receptor Signaling Pathway Protein Polyubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification By Small Protein Conjugation Post-translational Protein Modification Apoptotic Process Programmed Cell Death Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Family Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Catabolic Process Regulation Of Signal Transduction Transcription Elongation By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Myeloid Leukocyte Differentiation DNA-templated Transcription Elongation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation	MAP Kinase Kinase Activity JUN Kinase Kinase Activity Integrated Stress Response Signaling Intracellular Signaling Cassette Cellular Senescence Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Motor Neuron Apoptotic Process Response To Lipid RNA Polymerase II Transcription Regulator Complex Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Cellular Response To Lipid Cellular Response To Lipopolysaccharide Placenta Blood Vessel Development Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Response To Wounding MAPK Cascade Regulation Of Neuron Apoptotic Process Cellular Response To Interleukin-1 Fatty Acid Derivative Biosynthetic Process Fc Receptor Signaling Pathway Hepoxilin-epoxide Hydrolase Activity Lipoxin B4 Biosynthetic Process JNK Cascade Kinesin I Complex Negative Regulation Of Cell Adhesion Response To Lipopolysaccharide Malonyl-CoA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Fatty Acid Derivative Metabolic Process Cellular Response To Oxygen-containing Compound Acetyl-CoA Carboxylase Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leukotriene A4 Metabolic Process Lipoxin B4 Metabolic Process Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Negative Regulation Of Apoptotic Process Response To Molecule Of Bacterial Origin Response To Interleukin-1 Positive Regulation Of Osteoblast Differentiation Cellular Response To Stress Positive Regulation Of Cell Differentiation Granuloma Formation C/EBP Complex Protein Serine Kinase Activity
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