ADIPOR2 and ADIPOQ

Number of citations of the paper that reports this interaction (PubMedID 12802337)
0

Data Source:
HPRD (in vivo)

		ADIPOR2	ADIPOQ
Description		adiponectin receptor 2	adiponectin, C1Q and collagen domain containing
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Matrix Protein-containing Complex
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Hormone-mediated Signaling Pathway Fatty Acid Oxidation Adiponectin-activated Signaling Pathway Glucose Homeostasis Vascular Wound Healing Positive Regulation Of Cold-induced Thermogenesis	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Response To Nutrient Circadian Rhythm Response To Xenobiotic Stimulus Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Response To Nutrient Levels Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Adiponectin-activated Signaling Pathway Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of D-glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Cholesterol Import Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		AMPK inhibits chREBP transcriptional activation activity	AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases			Adiponectin deficiency
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Red cell distribution width ( 32888494) Urate levels in lean individuals ( 25811787)	Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 19165155 20011104 20018283 20876611 21700879 22479202 24105470 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Copper levels ( 26025379)
Interacting Genes		3 interacting genes: ADIPOQ APPL1 TMBIM6	62 interacting genes: ADIPOR2 AMIGO1 AQP6 ASGR2 BCL2L13 BIK BNIP3L BSND BTNL9 CAMLG CCDC107 CD200R1 CD79A CDH13 CLDN9 CLEC10A CLEC2D CNR2 COQ9 CPLX4 CREB3L1 CYBC1 ERGIC3 ERP29 FAM209A FASN FCGR1A FKBP7 FNDC9 GPR152 GPR42 HSD17B11 IFNGR2 KASH5 KCNK5 KEL MFF MFSD6 MRM1 MS4A3 MUC1 NEMP1 PEX12 PROKR2 PVR SCN3B SGTA SGTB SIGLEC12 SLC16A2 SLC22A23 SLC35E3 SLC35H1 SLC71A2 SYAP1 SYNE4 TMEM179B TMEM237 TMEM35A TMPRSS2 TNFSF14 TRIM35
Entrez ID		79602	9370
HPRD ID		06403	05671
Ensembl ID		ENSG00000006831	ENSG00000181092
Uniprot IDs		Q86V24	A8K660 B2R773 Q15848
PDB IDs		5LWY 5LX9 5LXA 6KS1 6YX9 6YXD 6YXF 6YXG	4DOU 6U66 6U6N
Enriched GO Terms of Interacting Partners?		Adiponectin-activated Signaling Pathway Negative Regulation Of Phagocytosis Negative Regulation Of Transport Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Localization Negative Regulation Of Immune System Process Regulation Of D-glucose Import Negative Regulation Of Endocytosis Regulation Of D-glucose Transmembrane Transport Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Phagocytosis Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Hormone-mediated Signaling Pathway Endoribonuclease Inhibitor Activity Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress Positive Regulation Of Macropinocytosis Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Transport Regulation Of Immune System Process Regulation Of Cholesterol Import Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Macropinosome Regulation Of Endocytosis Negative Regulation Of IRE1-mediated Unfolded Protein Response Response To Sucrose Response To Disaccharide Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Pinocytosis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Melanin Biosynthetic Process IRE1-mediated Unfolded Protein Response Cytokine-mediated Signaling Pathway Negative Regulation Of Granulocyte Differentiation	Membrane Protein Binding Plasma Membrane TRC Complex External Side Of Plasma Membrane Adiponectin Binding
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