PPM1E

Description		protein phosphatase, Mg2+/Mn2+ dependent 1E
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Signal Transduction Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)
Novel Interacting Genes		1 novel interacting genes: CCL19
Interacting Genes		5 interacting genes: ARHGEF7 DISC1 GAPDH PRKAA1 TNIK
Entrez ID		22843
HPRD ID		17888
Ensembl ID		ENSG00000175175
Uniprot IDs		Q8WY54
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Response To Prostaglandin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Neuron Cellular Homeostasis Positive Regulation Of Intracellular Signal Transduction Organelle Organization Regulation Of Cellular Component Organization TOR Signaling Regulation Of Developmental Process Negative Regulation Of Glucosylceramide Biosynthetic Process Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Microtubule Nucleation Positive Regulation Of Developmental Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Intracellular Chemical Homeostasis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of JNK Cascade CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Nervous System Development Glucose Metabolic Process Killing Of Cells Of Another Organism Regulation Of Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Peptidyl-cysteine S-nitrosylase Activity Cold Acclimation Positive Regulation Of Mitochondrial Transcription Cellular Homeostasis Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly CCR10 Chemokine Receptor Binding Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of JNK Cascade
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