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SMARCE1 and PSMC6
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
SMARCE1
PSMC6
Description
SWI/SNF related BAF chromatin remodeling complex subunit E1
proteasome 26S subunit, ATPase 6
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nuclear Matrix
SWI/SNF Complex
RSC-type Complex
Protein-containing Complex
Brahma Complex
NpBAF Complex
NBAF Complex
BBAF Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
N-acetyltransferase Activity
Nuclear Receptor Binding
Nucleosomal DNA Binding
Nucleotide Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Protein-macromolecule Adaptor Activity
Proteasome-activating Activity
Identical Protein Binding
Biological Process
Chromatin Organization
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Neurogenesis
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Regulation Of G0 To G1 Transition
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Double-strand Break Repair
Regulation Of Nucleotide-excision Repair
ERAD Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Formation of the canonical BAF (cBAF) complex
Formation of the polybromo-BAF (pBAF) complex
Formation of the embryonic stem cell BAF (esBAF) complex
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Asthma (
30929738
31619474
31959851
)
Asthma (childhood onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Eczema (
31361310
)
Triglyceride levels in HIV infection (
33109212
)
Prostate cancer (
23535732
)
Interacting Genes
94 interacting genes:
AMOTL2
AR
ARID2
BAZ1B
BRAP
BRMS1
CCDC136
CCDC172
CCDC183
CCHCR1
CDR2
CEBPA
CEP170P1
CEP63
CEP70
CYSRT1
DISC1
EPS8
ERG
ESR1
ESR2
EXOC4
EXOC7
FAM217B
FSD2
GATA1
GOLGA2
GOLGA6L9
GRIPAP1
HUNK
IFT74
IFT88
ING5
ITCH
JAKMIP2
KIFC3
KLF1
KRT14
KRT15
KRT16
KRT19
KRT27
KRT31
KRT34
KRT35
KRT37
KRT39
KRT40
KRTAP1-1
KRTAP10-8
KRTAP10-9
KRTAP6-3
MDM2
MED4
MEOX2
MIPOL1
MRFAP1L1
MTUS2
NBPF22P
NCOA1
NCOA2
NCOA3
NOTCH2NLA
NR0B2
NR3C1
NUP62
OGT
OIP5
PGR
PSMC6
RALBP1
RARB
RCOR1
RELB
RINT1
RSPH1
SIN3A
SIN3B
SMAD1
SMARCA4
SPAG5
SRC
STX11
SYCE1
TEX12
TFE3
TFIP11
TIAM1
TNIK
TRIM54
TRIP10
TXLNA
USHBP1
VPS52
19 interacting genes:
BYSL
C1orf216
CCDC146
CCDC85B
CCT2
CDC37
CDC42
CEBPA
CRK
CRKL
CYB5R2
GTF2A1
PAAF1
PSMA6
PSMD9
SDCBP
SEC14L5
SMARCE1
UBE2I
Entrez ID
6605
5706
HPRD ID
04382
04086
Ensembl ID
ENSG00000073584
ENSG00000100519
Uniprot IDs
Q969G3
A0A087X2I1
P62333
PDB IDs
6LTH
6LTJ
7CYU
7VDV
7Y8R
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
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Keratin Filament
Intermediate Filament
Structural Constituent Of Skin Epidermis
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Nuclear Receptor-mediated Signaling Pathway
Morphogenesis Of An Epithelium
Cytoskeleton
Tissue Morphogenesis
Estrogen Response Element Binding
Chromatin
Structural Molecule Activity
Protein Binding
Intracellular Receptor Signaling Pathway
Cytoskeleton Organization
Organelle Organization
Hormone-mediated Signaling Pathway
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Chromatin Binding
Steroid Binding
Nuclear Receptor Activity
Supramolecular Fiber Organization
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Epithelial Cell Differentiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Signal Transduction
Anatomical Structure Morphogenesis
Cellular Developmental Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Steroid Receptor Activity
Sin3-type Complex
Estrogen Receptor Signaling Pathway
Positive Regulation Of Stem Cell Population Maintenance
Cytosol
Positive Regulation Of RNA Metabolic Process
Epidermis Development
Cell Differentiation
DNA-binding Transcription Factor Activity
Protein-containing Complex
Cellular Response To Hormone Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Developmental Process
Transcription Repressor Complex
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Helper T Cell Diapedesis
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Diapedesis
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Endothelin Receptor Signaling Pathway
Regulation Of Cell Growth
Positive Regulation Of Receptor Clustering
Reelin-mediated Signaling Pathway
Postsynaptic Specialization Assembly
Establishment Of Cell Polarity
Regulation Of Receptor Clustering
Positive Regulation Of Rac Protein Signal Transduction
Kinase Binding
Mononuclear Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Locomotion
Regulation Of Growth
Positive Regulation Of Cell Motility
Positive Regulation Of Cell-substrate Adhesion
Nuclear Matrix
Postsynaptic Specialization Organization
Cellular Component Assembly
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Cell Growth
Establishment Or Maintenance Of Cell Polarity
T Cell Migration
Macrophage Differentiation
Positive Regulation Of Intracellular Signal Transduction
Protein-containing Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Phosphotyrosine Residue Binding
Dendrite Development
Positive Regulation Of Protein Localization
Central Nervous System Neuron Development
Purine Ribonucleoside Triphosphate Binding
Interleukin-5 Receptor Complex
SUMO Conjugating Enzyme Activity
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of T Cell Migration
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Leukocyte Migration
Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Signaling
GBD Domain Binding
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