SMARCE1 and ING5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SMARCE1	ING5
Description		SWI/SNF related BAF chromatin remodeling complex subunit E1	inhibitor of growth family member 5
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GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Neurogenesis Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Organization Regulation Of DNA-templated Transcription Protein Acetylation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Developmental Process Regulation Of Cell Cycle Apoptotic Signaling Pathway DNA Replication-dependent Chromatin Disassembly Regulation Of Hemopoiesis Regulation Of DNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 30929738 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Triglyceride levels in HIV infection ( 33109212)	Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet distribution width ( 32888494)
Interacting Genes		94 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEBPA CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ERG ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 HUNK IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OGT OIP5 PGR PSMC6 RALBP1 RARB RCOR1 RELB RINT1 RSPH1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TIAM1 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52	45 interacting genes: APC APLP1 ARFIP2 BARD1 BEX3 C3orf62 CBY2 CCDC33 CCHCR1 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH GGA1 GRIPAP1 HAP1 HGS HTT ICA1 IKZF3 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 ODF2 PCM1 PRMT5 RCOR3 SMARCE1 SUOX TADA3 TAF1D THAP6 TP53 TRIML2 VIM WASF1
Entrez ID		6605	84289
HPRD ID		04382	16348
Ensembl ID		ENSG00000073584	ENSG00000168395
Uniprot IDs		Q969G3	A0A1B0GW41 Q8WYH8
PDB IDs		6LTH 6LTJ 7CYU 7VDV 7Y8R	3C6W 5ME8 5MTO
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Receptor-mediated Signaling Pathway Morphogenesis Of An Epithelium Cytoskeleton Tissue Morphogenesis Estrogen Response Element Binding Chromatin Structural Molecule Activity Protein Binding Intracellular Receptor Signaling Pathway Cytoskeleton Organization Organelle Organization Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Steroid Binding Nuclear Receptor Activity Supramolecular Fiber Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Epithelial Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Sin3-type Complex Estrogen Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Cytosol Positive Regulation Of RNA Metabolic Process Epidermis Development Cell Differentiation DNA-binding Transcription Factor Activity Protein-containing Complex Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Developmental Process Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Identical Protein Binding Centriole Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Protein Binding Cytosol Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Domain Specific Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Centriole Replication P53 Binding Membrane Curvature Sensor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Organization Centriole Assembly Organelle Transport Along Microtubule Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transport Along Microtubule Regulation Of Cell Cycle G1/S Phase Transition Stress-induced Premature Senescence Protein-containing Complex Cytoskeleton-dependent Intracellular Transport Intracellular Transport Regulation Of Organelle Organization Microtubule-based Process Negative Regulation Of Mitotic Cell Cycle Nuclear Receptor Binding Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Centrosome Regulation Of DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Microtubule-based Transport Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Nucleoplasm Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centriole-centriole Cohesion Regulation Of Intracellular Protein Transport ATAC Complex Cellular Senescence Regulation Of Intracellular Transport Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Replicative Senescence
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